Inositol in combination with folic acid application in patients with polycystic ovary syndrome

Authors

  • A.N. Rybina
  • Yu.L. Tyugay
  • A.S. Tulepova
  • K.A. Urazymbetova
  • A.T. Abshekenova
  • R.K. Valiev

Keywords:

PCOS, inositol, pregnancy, ovulation stimulation, Fertina

Abstract

Introduction. Patients with polycystic ovary syndrome are a rather challenging group for fertility specialists. The
combination of endocrine and metabolic disorders in polycystic ovary syndrome (PCOS) requires a personalized approach
to each patient conception preparing. Inositol in combination with folic acid is one of the effective implements for metabolic
disorders correction in polycystic ovary syndrome.
Objectives: to determine the effectiveness of ovulation stimulation in patients with polycystic ovary syndrome during
preparation with inositol and folic acid - Fertina, OrionPharma.
Materials and methods: A prospective study was conducted from January 2019 to June 2019. 30 patients with polycystic
ovary syndrome were treated with Fertina combined drug containing 1 g of inositol and 100 μg of folic acid in a daily dose of 4
g of inositol and 400 μg of folic acid for 6 months. The levels of gonadotropins, insulin before and after the course of treatment
were determined, ultrasound monitoring of ovulation was carried out for 6 months.
Results: When Fertina prescribing 3 months before ovulation stimulation (OS), the LH / FSH ratio normalization and
decreased insulin levels were observed in patients with polycystic ovary syndrome. All 30 patients experienced ovulation, in
16.6% pregnancy occurred during 3 cycles of OS.

References

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Additional Files

Published

2019-10-01

How to Cite

[1]
Rybina А., Tyugay Ю., Tulepova А., Urazymbetova К., Abshekenova А. and Valiev Р. 2019. Inositol in combination with folic acid application in patients with polycystic ovary syndrome. Reproductive Medicine (Central Asia). 3 (40) (Oct. 2019), 25–28.

Issue

No. 3 (40) (2019): Reproductive medicine

Section

Статьи

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