Inositol in combination with folic acid application in patients with polycystic ovary syndrome

Authors

  • A.N. Rybina
  • Yu.L. Tyugay
  • A.S. Tulepova
  • K.A. Urazymbetova
  • A.T. Abshekenova
  • R.K. Valiev

Keywords:

PCOS, inositol, pregnancy, ovulation stimulation, Fertina

Abstract

Introduction. Patients with polycystic ovary syndrome are a rather challenging group for fertility specialists. The
combination of endocrine and metabolic disorders in polycystic ovary syndrome (PCOS) requires a personalized approach
to each patient conception preparing. Inositol in combination with folic acid is one of the effective implements for metabolic
disorders correction in polycystic ovary syndrome.
Objectives: to determine the effectiveness of ovulation stimulation in patients with polycystic ovary syndrome during
preparation with inositol and folic acid - Fertina, OrionPharma.
Materials and methods: A prospective study was conducted from January 2019 to June 2019. 30 patients with polycystic
ovary syndrome were treated with Fertina combined drug containing 1 g of inositol and 100 μg of folic acid in a daily dose of 4
g of inositol and 400 μg of folic acid for 6 months. The levels of gonadotropins, insulin before and after the course of treatment
were determined, ultrasound monitoring of ovulation was carried out for 6 months.
Results: When Fertina prescribing 3 months before ovulation stimulation (OS), the LH / FSH ratio normalization and
decreased insulin levels were observed in patients with polycystic ovary syndrome. All 30 patients experienced ovulation, in
16.6% pregnancy occurred during 3 cycles of OS.

References

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Additional Files

Published

2019-10-01

How to Cite

[1]
Rybina А., Tyugay Ю., Tulepova А., Urazymbetova К., Abshekenova А. and Valiev Р. 2019. Inositol in combination with folic acid application in patients with polycystic ovary syndrome. Reproductive Medicine. 3 (40) (Oct. 2019), 25–28.

Issue

No. 3 (40) (2019): Reproductive medicine

Section

Статьи

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