What should be done for men with sperm DNA fragmentation?
Keywords:
sperm DNA damage testing methods, sperm DNA fragmentation, infertile menAbstract
In an age when a small number of sperm can lead to pregnancy through in vitro fertilization or intracytoplasmic sperm
injection, selecting healthy sperm is important. Sperm DNA fragmentation (SDF) is known to be higher in infertile men.
Sperm DNA damage testing methods do not have clearly standardized cut-off levels and each method has its advantages and
disadvantages, making it difficult to proclaim one as a universally preferable method. It is best to select a testing method based on a patient’s clinical characteristics and goals.
Physicians and researchers working with ART must continue to make efforts to obtain healthy sperm with nuclear DNA
integrity to minimize the adverse effects that may arise in offspring conceived from sperm with DNA damage.
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