Genetic features of factors of innate immunity in the development of premature termination of pregnancy
Keywords:
miscarriage, factors of congenital immunity, allelic polymorphism, genotypeAbstract
RELEVANCE
Studying the mechanisms of regulation of innate immunity plays a crucial role in understanding the pathogenesis of miscarriage. Objective: to study the role of functional polymorphisms G753A in the TLR2 gene, C399T in the TLR4 gene and
G2848A in the TLR9 gene in the development of miscarriage in women of the Ukrainian population.
MATERIALS AND RESEARCH METHODS
DNA samples were analyzed in 139 women of the Ukrainian nation: 39 pregnant women with miscarriage and 100 pregnant
women with physiological pregnancy. Genotyping by polymorphic markers was performed: TLR2 (G753A), TLR4 (C399T),
TLR9 (G2848A). The multiplicative and general models of inheritance are used.
RESULTS
It was shown that when miscarriage of the A allele of the TLR 2 gene is shown to increase the chance of developing termination of pregnancy by 10.76 times, the GA genotype by 11.31; for the T allele of the TLR4 gene, this value is 1.75; for the CT genotype, 2.74; for the TLR9 gene A allele, the odds ratio is 2.44; for the GA genotype, 2.20.
FINDINGS
A study of the genetic characteristics of innate immunity factors in women of the Ukrainian nation showed that the carriage
of the A allele of the TLR2 and TLR9 genes and the T allele of the TLR4 gene increases the risk of premature termination of
pregnancy.
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