The informative value of coagulation parameter screening examination to predict early miscarriage: A literature review

Authors

  • D.V. Zubkov НАО "Медицинский университет Караганды"
  • D.Zh. Taizhanova
  • Zh.T. Amirbekova
  • G.S. Turdunova
  • N.V. Bespalova

DOI:

https://doi.org/10.37800/RM.3.2022.55-62

Keywords:

pregnancy, coagulopathy laboratory markers, thrombophilia, thrombosis, coagulation, reproductive losses

Abstract

Relevance: Assessment of gravida coagulation potential is one of the main components in predicting unfavorable reproductive outcomes. Such coagulation markers as prothrombin index (PTI), prothrombin time (PV), activated partial thromboplastin time (APTT), fibrinogen, and platelet index, are currently used in the first-trimester screening of pregnant women to detect
coagulopathies of various genesis. However, these markers have low prognostic efficacy. There is a need for more efficient laboratory markers to screen blood coagulation system disorders.
The study aimed to assess the prognostic value of coagulation markers (PTI, PV, APTT, fibrinogen, platelet counts) used in screening examinations of pregnant women in the first trimester to identify the risk of adverse pregnancy outcomes.
Methods: A literature search was carried out using PubMed, eLibrary, Cochrane, Scopus, and Web of Science databases. The search included clinical trials, meta-analyses, randomized controlled trials (RCTs), and systematic reviews published in the past decade. The search was done by keywords: “pregnancy,” “laboratory markers,” “coagulation,” and “miscarriage.”
Results: Currently, there is a question of revising and supplementing the existing screening markers of coagulation (PTI, APTT, Fibrinogen, platelet index) in favor of the latest markers presented: thrombomodulin (TM), thrombin-antithrombin complex (TAT), the complex of plasmin a2 inhibitors (PIC) and tissue plasminogen activator (tPAI-C). Considering their high importance in determining the coagulation potential of women of reproductive age as reliable markers of diagnosis of thrombosis with high sensitivity. This will significantly increase the efficiency of identifying individuals predisposed to coagulation disorders and reduce spontaneous reproductive losses.
Conclusion: New blood clotting markers TM, TAT, PIC, and tPAI-C offer high prognostic efficacy regarding violations of coagulation potential in pregnant women and high sensitivity regarding thrombosis. These markers require longer and deeper studies for diagnosing and predicting reproductive losses in women with negative pregnancy results in the first trimester.

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Published

2022-12-30

How to Cite

[1]
Zubkov Д., Taizhanova Д., Amirbekova Ж., Turdunova Г. and Bespalova Н. 2022. The informative value of coagulation parameter screening examination to predict early miscarriage: A literature review . Reproductive Medicine. 4(53) (Dec. 2022), 55–62. DOI:https://doi.org/10.37800/RM.3.2022.55-62.

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No. 4(53) (2022): Reproductive medicine

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Статьи

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