Features of the new coronavirus infection (COVID-19) in pregnant women
DOI:
https://doi.org/10.37800/RM.3.2023.27-34Keywords:
COVID-19, partial pneumonia, intoxication, myalgia, hemorrhagic syndrome, feverAbstract
Relevance: In 2019, a new coronavirus infection caused by the SARS-COV-2 virus was first detected in China in patients with pneumonia of unknown etiology. This issue is becoming relevant for doctors of all specialties, including obstetricians and Gynecologists. The features of the new coronavirus infection in pregnant women have not yet been studied, but we can draw some conclusions at this stage. Pregnancy is a special condition, and physiological norms during pregnancy can differ to a certain extent, so this should be considered when diagnosing and treating COVID-19.
The study aimed to explore the features of pregnancy in COVID-19-infected women and evaluate various complications and concomitant pathologies occurring during pregnancy.
Materials and Methods: Clinical observations and studies were performed from April 2020 to September 2021 at perinatal centers of the Turkestan region and the city of Shymkent and covered pregnant and postpartum women. Pregnant women with and without COVID-19 infection were given preliminary explanations on the study purpose and design and provided informed written consent.
Results: During the study, an intense deterioration was observed in 21 pregnant women with viral-bacterial pneumonia admitted to the intensive care unit. Acute respiratory viral infection was the most serious complication of influenza-related pneumonia in 80.9% (17/21) of patients. It developed 7.2±4.6 days after the first symptoms of the COVID-19 pandemic. Clinically, there was a rapid increase in symptoms of acute respiratory failure (tachypnea with more than 20 respiratory movements per minute, blood oxygen saturation with pulse oximetry of less than 90%), tachycardia, and arterial hypotension. The blood oxygen saturation averaged 84.4±5.1%, indicating the development of progressive hypoxemia and acute respiratory failure.
Conclusion: The COVID-19 virus was the leading cause of death in three pregnant women. Possible reasons for the fatal outcome included late seeking medical help and late initiation of etiotropic therapy, admission to a specialized hospital five days after the onset of the disease, lack of chemoprophylaxis, and a severe premorbid background.
References
Коронавирусная инфекция COVID-19 у взрослых: клинический протокол диагностики и лечения. Одо- брен ОККМУ МЗ РК 25 июля 2022 г., Протокол №166 [Koronavirusnaya infekciya COVID-19 u vzroslyx: klinicheskij protokol diagnostiki i lecheniya. Odobren OKKMU MZ RK 25 iyulya 2022 g., Protokol №166 (in Russ.)]. https://online.zakon.kz/Document/doc_id=36043894&pos=6;-106#pos=6;-106&sel_link=1009646761
Жабченко И.А., Геревич Н.В., Кравцова Ю.А., Сюдмак О.Р., Коваленко Т.Н., Бондаренко Е.Н., Лищенко И.С. Пери- натальные последствия COVID-19 (SARS-CoV-2): обзор литературы (часть I) // Репродуктивная медицина. – 2022. – №1(50). – С. 7-14. [Zhabchenko I.A., Gerevich N.V., Kravcova Ju.A., Sjudmak O.R., Kovalenko T.N., Bondarenko E.N., Lishhenko I.S. Perinatal'nye posledstvija COVID-19 (SARS-CoV-2): obzor literatury (chast' I) // Reproduktivnaja medicina. – 2022. – №1(50). – S. 7-14. (in Russ.).] https://doi.org/10.37800/RM.1.2022.7-14
Жабченко И.А., Геревич Н.В., Кравцова Ю.А., Сюдмак О.Р., Коваленко Т.Н., Бондаренко Е.Н., Лищенко И.С. Пери- натальные последствия COVID-19 (SARS-CoV-2): обзор литературы (часть II) // Репродуктивная медицина. – 2022. – №2(51). – С. 31-37. [Zhabchenko I.A., Gerevich N.V., Kravcova Ju.A., Sjudmak O.R., Kovalenko T.N., Bondarenko E.N., Lishhenko I.S. Perinatal'nye posledstvija COVID-19 (SARS-CoV-2): obzor literatury (chast' II) // Reproduktivnaja medicina. – 2022. – №2(51). – S. 31-37. (in Russ.)] https://doi.org/10.37800/RM.2.2022.31-37
Chen S., Liao E., Cao D., Gao Y., Sun G, Shao Y. Clinical analysis of pregnant women with 2019 novel coronavirus pneumonia // J. Med. Virol. – 2020. – Vol. 92 (9). – Р. 1556-1561. https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.25789
Chen H., Guo J., Wang C., Luo F., Yu X., Zhang W., Zhang Y. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records // Lancet. – 2020. – Vol. 395 (10226). – Р. 809-815. https://doi.org/10.1016/S0140-6736(20)30360-3
Favre G., Pomar L., Musso D., Baud D. 2019-nCoV epidemic: what about pregnancies? // Lancet. – 2020. – Vol. 395 (10224). – Art. no. e40. https://doi.org/10.1016/S0140-6736(20)30360-3
Mullins E., Evans D., Viner R.M., O'Brien P., Morris E. Coronavirus in pregnancy and delivery: rapid review // Ultrasound Obstet. Gynecol. – 2020. – Vol. 55(5). – P. 586‐592. https://doi.org/10.1002/uog.22014
Schwartz D.A., Graham A.L. Potential maternal and infant outcomes from coronavirus 2019-nCoV (SARS-CoV-2) infecting pregnant women: lessons from SARS, MERS, and other human coronavirus infections // Viruses. – 2020. – Vol. 12 (2). – Р. 194. https://doi.org/10.3390/v12020194
Panahi L., Amiri M., Pouy S. Risks of novel coronavirus disease (COVID-19) in pregnancy; a narrative review // Arch. Acad. Emerg. Med. – 2020. – Vol. 8(1). – Art. no. e34. https://pubmed.ncbi.nlm.nih.gov/32232217/
Zaigham M., Andersson O. Maternal and perinatal outcomes with COVID‐19: a systematic review of 108 pregnancies // Acta Obstet. Gynecol. Scand. – 2020. – Vol. 99 (7). – Р. 823-829. https://doi.org/10.1111/aogs.13867
Hantoushzadeh S., Shamshirsaz A.A., Aleyasin A., Seferovic M.D., Aski S.K., Arian S.E., Pooransari P., Ghotbizadeh F., Aalipour S., Soleimani Z., Naemi M., Molaei B., Ahangari R., Salehi M., Oskoei A.D., Pirozan P., Darkhaneh R.F., Laki M.G., Farani A.K., Atrak S., Miri M.M., Kouchek M., Shojaei S., Hadavand F., Keikha F., Hosseini M.S., Borna S., Ariana S., Shariat M., Fatemi A., Nouri B., Nekooghadam S.M., Aagaard K. Maternal death due to COVID-19 // Am. J. Obstet. Gynecol. – 2020. – Vol. 223(1). – P. 109.e1-109.e16. https://doi.org/10.1016/j.ajog.2020.04.030
Chen D., Yang H., Cao Y., Cheng W., Duan T., Fan C., Fan S., Feng L., Gao Y., He F., He J., Hu Y., Jiang Y., Li Y., Li J., Li X., Li X., Lin K., Liu C., Liu J., Liu X., Pan X., Pang Q., Pu M., Qi H., Shi C., Sun Y., Sun J., Wang X., Wang Y., Wang Z., Wang Z., Wang C., Wu S., Xin H., Yan J., Zhao Y., Zheng J., Zhou Y., Zou L., Zeng Y., Zhang Y., Guan X. Expert consensus for managing pregnant women and neonates born to mothers with suspected or confirmed novel coronavirus (COVID‐19) infection // Int. J. Gynecol. Obstet. – 2020. – Vol. 149 (2). – Р. 130-136. https://doi.org/10.1002/ijgo.13146
Davanzo R. Breast feeding at the time of COVID-19: do not forget expressed mother’s milk, please // Arch. Dis. Child. Fetal Neonatal Ed. – 2020. – Vol. 105 (4). – Р. 455. https://doi.org/10.1136/archdischild-2020-319149
Liu D., Li L., Wu X., Zheng D., Wang J., Liang B., Yang L., Zheng C. Pregnancy and perinatal outcomes of women with coronavirus disease (COVID-19) pneumonia: A preliminary analysis // AJR. – 2020. – Vol. 215. – P. 127-132. https://www.ajronline.org/doi/pdfplus/10.2214/AJR.20.23072?src=recsys
Lacro U. COVID-19 Preparedness and Response – UNFPA Interim Technical Briefs Gender Equality and GBV. https://policycommons.net/artifacts/3824377/covid-19-preparedness-and-response/4630293/. 23 March 2020.
Jardine J., Relph S., Magee L.A., von Dadelszen P., Morris E., Ross‐Davie M., Khalil A. Maternity services in the UK during the coronavirus disease 2019 pandemic: a national survey of modifications to standard care // BJOG. – 2021. – Vol. 128 (5). – Р. 880-889. https://doi.org/10.1111/1471-0528.16547
Qiao J. What are the risks of COVID-19 infection in pregnant women? // Lancet. – 2020. – Vol. 395 (10226). – Р. 760-762. https://doi.org/10.1016/S0140-6736(20)30365-2
Коронавирусная инфекция (COVID-19) у беременных, рожениц и родильниц. Версия: Клинические протоколы МЗ РК – 2022 (Казахстан). Одобрен ОККМУ МЗ РК 04 марта 2022 г., Протокол №158 [Koronavirusnaya infekciya (COVID-19) u beremennyx, rozhenic i rodil'nic. Versiya: Klinicheskie protokoly MZ RK – 2022 (Kazaxstan). Odobren OKKMU MZ RK 04 marta 2022 g., Protokol №158 (in Russ.)]. https://diseases.medelement.com/disease/коронавирусная-инфекция-covid-19-у-беременных-рожениц-и-родильниц-кп-рк-3-редакция-2022/17139
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