The importance of various factors in the development of female primary infertility: A literature review

Authors

  • G.A. Zhurabekova
  • G.K. Toichiyeva МКЦР "PERSONA"
  • L.K. Sarsenova
  • Zh. Oralkhan
  • N.V. Bershina
  • А.K. Berdalinova
  • L.Sh. Bimaganbetova
  • O.V. Kim
  • А.D. Balmagambetova
  • T.A. Akhayeva

DOI:

https://doi.org/10.37800/RM.4.2023.58-66

Keywords:

primary infertility, ovarian reserve, reproductive biomarkers, smoking and infertility, healthy lifestyle, stress and infertility, meta-analysis of infertility

Abstract

Relevance: Infertility is a global public health problem and a socially destabilizing condition for couples suffering from multiple factors, including medical, social, and psychological stress and marital discord. About 10-15% of couples worldwide suffer from infertility.
The study aimed to determine risk factors for infertility in women of fertile age.
Materials and Methods: The keywords used in the search were: “primary infertility,” “ovarian reserve,” “reproductive biomarkers,” “smoking and infertility,” “healthy lifestyle,” “stress and infertility,” “meta-analysis of infertility,” in PubMed, Web of Science, Embase, and Google Scholar databases, articles published July 2017-2022.
Results: The analysis shows that socio-demographic indicators, women’s age, stress, diseases of the reproductive system, infectious diseases, the current level of education of women, social status, and lifestyle factors are predictors of primary infertility.
Medical professionals can use this study results to develop effective methods for solving infertility problems in which psycho-emotional and social interventions have a positive effect on pregnancy rates.
Conclusion: Thus, these studies provide the basis for making recommendations for specific preventive and educational programs and can serve as a basis for counseling women facing infertility in the future.

References

Всемирная организация здравоохранения. Бесплодие.

World Health Organization. Infertility. (In Russ.). [Internet]. Updated 2023 Apr 03; cited 2023 Nov 16.

Available from: https://www.who.int/ru/news-room/fact-sheets/detail/infertility

Шкарин В.В., Саперкин Н.В. Влияние отдельных оппортунистических инфекций и инфекций, передаваемых половым путем, на демографические процессы. Комплексная коморбидность. Акушерство и гинекология. 2021;4:32-40.

Shkarin VV, Saperkin NV. The influence of certain opportunistic infections and sexually transmitted infections on demographic processes. Complex comorbidity. Akusherstvo i ginekologiya. 2021;4:32-40. (In Russ.).

https://dx.doi.org/10.18565/aig.2021.4.32-40

National Center for Health Statistics. Infertility. [Internet]. Updated 2023 Nov 03; cited 2023 Nov 16. Available from: https://www.cdc.gov/nchs/fastats/infertility.htm

Nafees R, Khan HL, Zareen H, Imran Z, Sher SJ. Myths and controversies in Assisted Reproductive Techniques – gynecologists’ perspective. Biomedica. 2020;3(36):115.

https://biomedicapk.com/files/articles/pdf/115/show

Langarizadeh М, Fatemi Aghda SA, Nadjarzadeh А. Design and evaluation of a mobile-based nutrition education application for infertile women in Iran. BMC Medical Informatics and Decision Making. 2022;22(1):58.

https://doi.org/10.1186/s12911-022-01793-x.

Akalewold М, Yohannes GW, Abdo ZA, Hailu Y, Negesse A. Magnitude of infertility and associated factors among women attending selected public hospitals in Addis Ababa, Ethiopia a cross-sectional study. BMC Women's Health. 2022;22:11.

https://bmcwomenshealth.biomedcentral.com/articles/10.1186/s12905-022-01601-8

Bagade Т, Thapaliya К, Breuer Е, Kamath R, Li Z, Sullivan E, Majeed T. Investigating the association between infertility and psychological distress using Australian Longitudinal Study on Women's Health (ALSWH). Scientific Reports. 2022;12(1):10808.

https://doi.org/10.1038/s41598-022-15064-2.

Локшин В.Н., Сулейменова М.Д., Карибаева Ш.К., Джусубалиева Т.М., Байкошкарова С.Б., Отарбаев М.К., Ахметова А.А., Покотило Л.И., Макишева А.Т., Тарарака К.С., Тарарака С.С., Чалов Л.Р., Ким Н.С., Молбаев А.Т., Имтосими Д.Г., Лапина Е.В. Вспомогательные репродуктивные технологии в Казахстане за 2019 год: данные национального регистра. Репрод Мед. 2022;3(52):7-14.

Lokshin VN, Sulejmenova MD, Karibaeva ShK, Dzhusubalieva TM, Bajkoshkarova SB, Otarbaev MK, Ahmetova AA, Pokotilo LI, Makisheva AT., Tararaka KS, Tararaka SS, Chalov LR, Kim NS, Molbaev AT, Imtosimi DG, Lapina EV. Assisted reproductive technologies in Kazakhstan for 2019: data from the national register. Reprod Med. 2022;3(52):7-14. (In Russ.).

https://doi.org/10.37800/RM.3.2022.7-14

Gnot С. Natural Fertility and Age. Gynecological Endocrinology. 2020;18;81-87.

https://gremjournal.com/wp-content/uploads/2020/11/Abstract-Book-GREM.pdf

Katole A, Saoji A. Prevalence of primary infertility and its associated risk factors in urban population of central India: A community-based cross-sectional study. Indian J Community Med. 2019;44(4):337-341.

https://doi.org/10.4103/ijcm.IJCM_7_19

Sanghavi P, Savsaiya B, Patel H, Patel K, Chandel D. Factors Affecting Female Infertility in the Population of Gujarat (India). J. Gynäkol. Endokrinol./Österreich. 2022;33:3.

https://doi.org/10.1007/s41974-022-00240-z

Александрова Н.В. Антимюллеров гормон и его прогностическая значимость для оценки качества ооцитов. Гинекология. 2020;6(22):21-26.

Aleksandrova NV. Anti-Mullerian hormone and its prognostic significance for assessing the quality of oocytes. Ginekologija. 2020;6(22):21-26. (In Russ.).

https://doi.org/10.26442/20795696.2020.6.200473

Шишиморова С.И., Тевкин Т.М., Джусубалиева М.С. Женщины 40+ в "свежих" недонорских программах ВРТ: шанс на успех? Репрод Мед. 2022;3(52):24-33.

Shishimorova SI, Tevkin TM, Dzhusubalieva MS. Women 40+ in “fresh” non-donor ART programs: any chance for success? Reprod Med. 2022;3(52):24-33. (In Russ.).

https://doi.org/10.37800/RM.3.2022.24-33

Salama S., Sharaf M, Salem SM, Abdel Rasheed M, Salama E, Elnahas T, Lotfy R. FSH versus AMH: age-related relevance to ICSI results. Middle East Fertil Soc J. 2021;26(1):27.

https://doi.org/10.1186/s43043-021-00071-6

Paira DA, Molina G, Tissera AD, Olivera C, Molina RI, Motrich RD. Results from a large cross-sectional study assessing Chlamydia trachomatis, Ureaplasma spp. and Mycoplasma hominis urogenital infections in patients with primary infertility. Sci Rep. 2021;11(1):13655.

https://doi.org/10.1038/s41598-021-93318-1

Zhang Z, Li Y, Lu H, Li D, Zhanga R, Xie X, Guo L, Hao L, Tian X, Yang Z, Wang S, Mei X. A systematic review of the correlation between Trichomonas vaginalis infection and infertility. Acta Tropica. 2022;236:106693.

https://doi.org/10.1016/j.actatropica.2022.106693

Wang L, He L, Chen J, Wei S, Xu H, Luo M. HPV and vaginal microecological disorders in infertile women: a cross-sectional study in the Chinese population. Virology J. 2022;19:137.

https://virologyj.biomedcentral.com/articles/10.1186/s12985-022-01869-0

Li L, Li C, Sun X, Liu J, Zheng H, Yang B, Tang W, Wang C, Chlamydia infection, PID, and infertility: further evidence from a case–control study in China. BMC Women's Health. 2022;22:294.

https://doi.org/10.1186/s12905-022-01874-z

Бахарева И.В. Роль вагинальной микробиоты в сохранении женского репродуктивного здоровья: обзор литературы (часть 2). Репродуктивная медицина. 2022;2(51):45-54.

Bahareva IV. The role of vaginal microbiota in maintaining female reproductive health: A literature review (Part 2). Reprod med. 2022;2(51):45-54. (in Russ.).

https://doi.org/10.37800/RM.2.2022.45-54

Eroglua S, Asginb N. Bacterial vaginosis and Mycoplasma infections in reproductive-age women: Clarifying the association with risk. Clínica e Investigación en Ginecología y Obstetricia. 2022;49(4):100769.

https://doi.org/10.1016/j.gine.2022.100769

Khikmatova IN, Pakhomova YJ, Ruzieva KhN. Assessment of the intestinal and vagina microbioma during extracorporal fertilization programs. Sys Rev Pharm. 2020;11(11):965-969.

https://doi.org/10.31838/srp.2020.11.138

Maeda E, Jwa SC, Kumazawa Y, Saito K, Iba A, Yanagisawa‑Sugita A, Kuwahara A, Saito H, Terada Y, Fukuda T, Ishihara O, Kobayashi Y. Out-of-pocket payment and patients’ treatment choice for assisted reproductive technology by household income: a conjoint analysis using an online social research panel in Japan. BMC Health Services Research. 2022;22:1093.

https://doi.org/10.1186/s12913-022-08474-5.

Katole A, Saoji A. Prevalence of primary infertility and its associated risk factors in urban population of central India: A community-based cross-sectional study. Indian J Community Med. 2019;44(4):337-341.

https://doi.org/10.4103/ijcm.IJCM_7_19

Тойчиева Г.К., Оралхан Ж., Аленова А.А., Саханова С.К., Бердалинова А.К., Журабекова Г.А. Исследование взаимосвязи показателей овариального резерва и влияния факторов образа жизни при первичном бесплодии. Репрод Мед. 2022;3(52):34-40.

Tojchieva GK, Oralhan Zh, Alenova AA, Sahanova SK, Berdalinova AK, Zhurabekova GA. Study of the relationship between ovarian reserve indicators and the influence of lifestyle factors in primary infertility. Reprod med. 2022;3(52):34-40. (in Russ.).

https://doi.org/10.37800/RM.3.2022.34-40.

Purkayastha N, Sharma H. Prevalence and potential determinants of primary infertility in India: Evidence from Indian demographic health survey. Clin Epidemiol Global Health. 2021;9:162-170.

https://doi.org/10.1016/j.cegh.2020.08.008

Dhair А, Abed Y. The association of types, intensities and frequencies of physical activity with primary infertility among females in Gaza Strip, Palestine: A case-control study. PLoS One. 2020;15(10):e0241043.

https://doi.org/10.1371/journal.pone.0241043

Xie F, You Y, Guan C, Gu Y, Yao F, Xu J. Association between physical activity and infertility: a comprehensive systematic review and meta-analysis. J Translational Med. 2022;20:237.

https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-022-03426-3

Miller N, Pasternak Y, Herzberger E, Gluska H, Dorenstein C, Rahav R, Hemi R, Zada N, Wise A. High physical activity and ovarian reserve: a prospective study of normo-ovulatory professional athletes. J Ovarian Res. 2022;15:107.

https://ovarianresearch.biomedcentral.com/articles/10.1186/s13048-022-01040-x

Neamtiu IA, Surcel M, Begum TF, Gurzau ES, Berindan-Neagoe I, Braicu C, Rotar I, Muresan D, Bloom MS. Specific lifestyle factors and in vitro fertilization outcomes in Romanian women: a pilot study. Peer J. 2022;4(10):e14189.

https://peerj.com/articles/14189/

Ma M, Guo L, Liu X, Zheng Y, Gu C, Li B. Genetic correlation between female infertility and mentalhealth and lifestyle factors: A linkage disequilibrium scoreregression study. Health Sci Rep. 2022;5:e797.

https://doi.org/10.1002/hsr2.797

Kohil A, Chouliaras S, Alabduljabbar S, Lakshmanan AP, Ahmed SH, Awwad J, Terranegra A. Female infertility and diet, is there a role for a personalized nutritional approach in assisted reproductive technologies? A Narrative Review. Front Nutr. 2022;22(9):927-972.

https://doi.org/10.3389/fnut.2022.927972

Nagórska M, Lesińska-Sawicka M, Obrzut B, Ulman D, Darmochwał-Kolarz D, Zych B. Health Related Behaviors and Life Satisfaction in Patients Undergoing Infertility Treatment. Int J Environ Res Public Health. 2022;19(15):9188.

https://doi.org/10.3390/ijerph19159188

Palomba S, Daolio J, Romeo S, Battaglia FA, Marci R, La Sala GB. Lifestyle and fertility: the influence of stress and quality of life on female fertility. Reprod Biol Endocrinol. 2018;16(1):113.

https://doi.org/10.1186/s12958-018-0434-y.

Suleimenova M, Lokshin V, Glushkova N, Karibayeva S, Terzic M. Quality-of-Life Assessment of Women Undergoing In Vitro Fertilization in Kazakhstan. Int J Environ Res Public Health. 2022;19(20):13568.

https://doi.org/10.3390/ijerph192013568

Kim NI, Chamchan C, Tangchonlatip K. Prevalence and Social Risk Factors of Infertility in Vietnam. Illness, Crisis & Loss. 2021;4:756-769.

https://doi.org/10.1177/10541373211022103

Afferri A, Allen H, Dierickx S, Bittaye M, Marena M, Pacey A, Balen J. Availability of services for the diagnosis and treatment of infertility in The Gambia`s public and private health facilities: a cross-sectional survey. BMC Health Services Research. 2022;22:1127.

https://doi.org/10.1186/s12913-022-08514-0.

Hoang K, Evans N, Aghajanova L, Talib H, Linos E, Gold JM. Fertility Benefits at Top U.S. Medical Schools. J Women's Health. 2022;31:9.

https://doi.org/10.1089/jwh.2021.0486

Zhang L, Shao H, Huo M, Chen J, Tao M, Liu Z. Prevalence and associated risk factors for anxiety and depression in infertile couples of ART treatment: a cross-sectional study. BMC Psychiatry. 2022;22:616.

https://bmcpsychiatry.biomedcentral.com/articles/10.1186/s12888-022-04256-9

Published

2023-12-30

How to Cite

[1]
Zhurabekova Г., Toichiyeva Г. , Sarsenova Л., Oralkhan Ж. , Bershina Н., Berdalinova А. , Bimaganbetova Л., Kim О., Balmagambetova А. and Akhayeva Т. 2023. The importance of various factors in the development of female primary infertility: A literature review . Reproductive Medicine (Central Asia). 4 (Dec. 2023), 67–77. DOI:https://doi.org/10.37800/RM.4.2023.58-66.

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