Association of obesity with hematological indicators of inflammation in pregnant women
DOI:
https://doi.org/10.37800/RM.1.2024.60-66Keywords:
pregnancy, obesity, inflammation, BMI, anemia, markers of inflammationAbstract
Relevance: Obesity is the abnormal or excessive accumulation of fat that harms health. Many studies have shown that obesity causes an inflammatory response, leading to anemia and other adverse pregnancy outcomes. Our study aimed to examine the association between hematological markers of inflammation and obesity during pregnancy.
The study aimed to evaluate the relationship between hematological markers of inflammation and obesity in pregnant women with anemia.
Materials and Methods: The studies were conducted in the perinatal center at the regional clinical hospital in Karaganda. The clinical study enrolled 92 pregnant women between 2021 and 2022. Clinical data of patients located in the electronic archive of a medical organization was retrospectively analyzed. All examined women were divided into 4 groups: group 1 (n=25) – practically healthy (pregnant women without obesity and anemia); Group 2 (n=22) – pregnant women with anemia without obesity); Group 3 (n=23) – obese pregnant women without anemia; Group 4 (n=22) – pregnant women with obesity and anemia.
Results: A detailed comparative analysis of hematological markers of peripheral blood revealed statistically significant differences (p>0.05) between groups in hemoglobin, erythrocyte sedimentation rate (ESR), lymphocytes, band neutrophils, and eosinophils. According to the Mann- Whitney test, a few hematological parameters, such as red blood cells, platelets, and hematocrit values, were equivalent in the 3 and 4 groups (obese pregnant women). In addition, the level of leukocytes, band neutrophils, lymphocytes, and eosinophils in these groups was higher than in 1 and 2 groups (women without obesity) (p<0.05).
Conclusion: Hematological markers of inflammation (leukocytes, neutrophils, and lymphocytes) were higher in pregnant women with obesity than in groups of healthy pregnant women (without obesity and anemia) and with anemia. It may predict adverse obstetric and neonatal outcomes in pregnant women.
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