Immunological features of community-acquired pneumonia in children vaccinated with pneumococcal vaccine
DOI:
https://doi.org/10.37800/RM.2.2024.128-135Keywords:
Streptococcus pneumoniae, vaccination, MCP-1, childrenAbstract
Relevance: Recently, it remains important to study the activation of protective and adaptive systems of the microorganism in the fight against a pathogenic agent. At the same time, cytokines perform the main regulatory function as mediators of intercellular interaction.
The study aimed to identify the immunological features of community-acquired pneumonia in vaccinated children to assess their impact on the severity of the disease.
Materials and methods: We conducted a study to identify the immunological features of community-acquired pneumonia in vaccinated children. The study included 80 children aged 2 months to 3 years, with varying degrees of severity of community-acquired pneumonia, hospitalized in the city of Karaganda in 2017-2020. The children were divided into 2 groups. The first group included vaccinated children (n=407), and the second group included children with vaccination disorders (n=40). The control group consisted of 20 children. The results were calculated and evaluated on an IBM-compatible computer with the Windows XP operating system using the MS Excel 2017 (Microsoft) software package, SPSS 12.0.2, and Statistica 20. The statistical analysis was carried out using the STATISTICA package. The Mann-Whitney criterion was calculated to compare the significance of differences in groups. The differences were considered statistically significant at p<0.05.
Results: The determination of this marker revealed a significant increase in the proinflammatory cytokine MCP-1 in urine (p<0.05) in children with impaired immunization timing with severe course of VP, in contrast to the group of vaccinated children. Thus, in children, this indicator was 7.8 (5.03; 9.07) pg/ml Me (Lq; Uq), and in children with impaired immunization – 18.4 (6.22; 30.08) pg/ml Me (Lq; Uq) (p=0.026913).
Conclusion: The immunological research methods used by us can increase the effectiveness of timely diagnosis of community-acquired pneumonia in children vaccinated with pneumococcal vaccine at the inpatient level, as well as improve the individual prognosis of the course of the disease.
References
Phung TTB, Suzuki T, Phan PH, Kawachi S, Furuya H, Do HT, Kageyama T, Ta TA, Dao NH, Nunoi H, Tran DM, Le HT, Nakajima N. Pathogen screening and prognostic factors in children with severe ARDS of pulmonary origin. Pediatr Pulmonol. 2017;52(11):1469-1477.
https://doi.org/10.1002/ppul.23694
Xu X.F, Li X.J, Liu J.L, Wu L, Chen Z.M. Serum cytokine profile contributes to discriminating M. pneumoniae pneumonia in children.
Cytokine. 2016;86:73-78.
https://doi.org/10.1016/j.cyto.2016.07.018
Zhang Y, Mei S, Zhou Y, Huang M, Dong G, Chen Z. Cytokines as the good predictors of refractory Mycoplasma pneumoniae
pneumonia in school-aged children. Sci. Rep. 2016;6:370.
http://dx.doi.org/10.1038/srep37037
Yong KK, Chang JH, Chien MH, Tsao SM, Yu MC, Bai KJ, Tsao TC, Yang SF. Plasma Monocyte Chemoattractant Protein-1 Level as a
Predictor of the Severity of Community-Acquired Pneumonia. Int J Mol Sci. 2016;17(2):E179.
https://doi.org/10.3390/ijms17020179
Pizzutto SJ, Upham JW, Yerkovich ST, Chang AB. High Pulmonary Levels of IL-6 and IL-1β in Children with Chronic Suppurative Lung Disease Are Associated with Low Systemic IFN-γ Production in Response to Non-Typeable Haemophilus influenzae. PLoS One.
;10(6):e0129517.
https://doi.org/10.1371/journal.pone.0129517
He J, Qu H, Gao CY. Association between inflammation factors and Mycoplasma pneumoniae in children. Medicine (Baltimore). 2019;98(15):e15118.
https://doi.org/10.1097%2FMD.0000000000015118
Vasconcellos ÂG, Clarêncio J, Andrade D, Cardoso MA, Barral A, Nascimento-Carvalho CM. Systemic cytokines and chemokines on admission of children hospitalized with community-acquired pneumonia. Cytokine. 2018;107:1-8.
https://doi.org/.1016/j.cyto.2017.11.005
Yu ZW, Qian J, Gu XH, Zhang XJ, Pan JR, Ju HL. Changes in serum inflammatory factors in wheezing infants with community-acquired pneumonia. Zhongguo Dang Dai Er Ke Za Zhi. 2015;17(8):815-818.
https://doi.org/10.7499/j.issn.1008-8830.2015.08.011
De Brito RC, Lucena-Silva N, Cavalcante Torres L, Luna CF, Correia JB, Da Silva GA. The balance between the serum levels of IL-6 and IL-10 cytokines discriminates mild and severe acute pneumonia. BMC Pulmonary Medicine. 2016;16(1):170.
https://doi.org/10.1186/s12890-016-0324-z
Sun L, Cornell TT, LeVine A, Berlin AA, Hinkovska-Galcheva V, Fleszar AJ, Lukacs NW, Shanley TP. Dual role of interleukin-10 in the regulation of respiratory syncitial virus (RSV) - induced lung inflammation. Clin Exp Immunol. 2013;172(2):263-269.
https://doi.org/10.1111/cei.12059
Kapanadze N, Pantsulaia I, Chkhaidze I. Сytokines profile and its connection with disease severity in community-acquired pediatric
pneumonia. Georgian Med News. 2018;(284):103-108.
http://dx.doi.org/10.21292/2075-1230-2021-99-4-36-43
Vasconcellos ÂG, Clarêncio J, Andrade D, Cardoso MRA, Barral A, Nascimento-Carvalho CM. Systemic cytokines and chemokines on
admission of children hospitalized with community-acquired pneumonia. Cytokine. 2018;107:1-8.
https://doi.org/10.1016/j.cyto.2017.11.005
Туктибаева С.А, Жолымбекова Л.Д, Саркулова И.С, Рыскельдиева К.Н. Жаңа коронавирустық инфекцияның (COVID-19) жүкті
әйелдердегі ерекшеліктері // Репрод Мед. 2023;3(56):27-34.
Tuktibaeva S.A, Zholymbekova L.D, Sarkulova I.S, Ryskel'dieva K.N. Features of the new coronavirus infection (COVID-19) in pregnant women. Reprod Med. 2023;3(56):27-34. (Kazakh.)
https://doi.org/10.37800/RM.3.2023.27-34
Пневмония у детей: клинический протокол. Утв. Объединенной комиссией по качеству медицинских услуг МЗ РК 05.10.2017, №29.
Pneumonia in children: clinical protocol. Approved Joint Commission on the Quality of Medical Services of the Ministry of Health of the Republic of Kazakhstan 10/05/2017, No. 29. (Russian).
https://diseases.medelement.com/disease/пневмония-у-детей-2017/15423
Всемирная организация здравоохранения. Интегрированное ведение болезней детского возраста. – Париж, 2000. – 204 с. World Health Organization. Handbook: IMCI Integrated Management of Childhood Illnesses. – Paris, 2000. – 204 p. (Russian).
https://iris.who.int/handle/10665/92106
Ахаева А.С. Анализ взаимосвязей уровня прокальцитонина при внебольничной пневмонии у детей. Медицина и экология.
;3:84-87.
Ahaeva AS. Analysis of relationships between procalcitonin levels in community-acquired pneumonia in children. Meditsina i ekologiya. 2017;3:84-87 (Russian).
https://webirbis.qmu.kz/en/lib/document/KTSA/3CEB5F5C-4769-448D-A2FD-DD2306F271EE/
Буланов Н.М., Серова В.Г., Кузнецова Е.И. Молекулы повреждения почечной ткани (KIM-1, MCP-1) и коллаген IV типа в оценке активности ассоциированного с антинейтрофильными цитоплазматическими антителами гломерулонефрита. Терапевтический архив. 2017;6(86):48-55.
Bulanov NM, Serova VG, Kuznecova EI. Renal tissue damage molecules (KIM-1, MCP-1) and type IV collagen in assessing the activity of antineutrophil cytoplasmic antibodies associated glomerulonephritis. Terapevticheskij arhiv. 2017;6(86):48-55 (Russian).
https://doi.org/10.17116/terarkh201789648-55
Коломеец Н.Ю, Аверьянова Н.И, Щекотова А.П. Исследование экскреции с мочой моноцитарного хемоаттрактантного протеина-1 как метод мониторинга активности воспалительного процесса в интерстициальной ткани почек у детей с гломерулонефритом. Методы диагностики и технологии. 2012;4(29):72-77.
Kolomeec NJu, Aver'janova NI, Shhekotova AP. Study of urinary excretion of monocyte chemoattractant protein-1 as a method for monitoring the activity of the inflammatory process in the interstitial tissue of the kidneys in children with glomerulonephritis. Metody
diagnostiki i tehnologii. 2012;4(29):72-77. (Russ.).
Panee J. Monocyte Chemoattractant Protein 1 (MCP-1) in obesity and diabetes. Cytokine. 2012;1(60):1-12.
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