Antiphospholipid antibodies in the pathogenesis of obstetric pathology: a literature review
DOI:
https://doi.org/10.37800/RM.4.2024.402Keywords:
antiphospholipid syndrome, antiphospholipid antibodies, non-critical antibodies, miscarriage, implantation disorders, preeclampsiaAbstract
Relevance: The relevance of antiphospholipid syndrome research continues to grow in light of its high prevalence, complexity of diagnosis and treatment, and impact on reproductive health. Repeated pregnancy losses and implantation failure during repeated attempts at in vitro fertilization and embryo transfer, as well as preeclampsia during pregnancy, can seriously affect the quality of life of patients. The relationship between preeclampsia and antiphospholipid syndrome is based on common pathophysiological mechanisms associated with impaired vascular function and increased susceptibility to thrombosis, which can worsen the course of pregnancy and cause complications. New discoveries in this area can lead to improved diagnosis, treatment, and prevention, which will ultimately improve the quality of life of patients facing this serious medical condition.
The study aimed to identify the role of antiphospholipid antibodies in the pathogenesis of obstetric pathology (miscarriage, recurrent implantation disorders, early preeclampsia).
Materials and methods: An analysis of 24 articles out of 140 publications in the Google Scholar, Willey, PubMed databases was conducted using keywords such as "antiphospholipid syndrome", "antiphospholipid antibodies", "non-criterial antibodies", "miscarriage", "recurrent implantation disorders", "preeclampsia". Using the filter "all article types", "Full text, free access" - 102 publications were found. Continuing the selection for the last 10 years - 24 articles included in the review, published from 2015 to 2023.
Results: The article presents global data on the impact of antiphospholipid syndrome (APS) on the implantation process in IVF programs, early pregnancy. A review of data on the combination of APS with hypertensive conditions during pregnancy was also conducted. Timely diagnostics and monitoring of laboratory data of the hemostasis system opens up prospects for the development of potential biomarkers for the prediction of habitual miscarriage and recurrent implantation disorders in APS and hypertensive conditions during pregnancy.
Conclusion: Timely diagnosis and monitoring of laboratory parameters of the hemostasis system open up prospects for the development of potential biomarkers for the prediction of habitual miscarriage and recurrent implantation disorders in APS and hypertensive conditions during pregnancy, which has potential significance for improving the quality of life of patients.
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