In-vitro activation of ovarian follicular residual reserve

Authors

  • E. Girsh
  • A. Harlev
  • L. Grin

DOI:

https://doi.org/10.37800/RM2020-1-34

Keywords:

premature ovarian insufficiency, in-vitro activation (IVA) method, poor ovarian response (POR)

Abstract

The newly developed in-vitro activation (IVA) method provides a novel fertility treatment for patients with premature ovarian
insufficiency. The IVA method pretends to promote growth of residual ovarian follicles at early stages of their development. Based
on preliminary data, poor ovarian response (POR) patients with decreased ovarian reserve (DOR) who have multiple secondary
follicles, IVA is a promising technique to promote growth of secondary follicle as well.

References

Block E. Quantitative morphological investigations of the follicular system in women; variations at different ages. Acta Anat. 1952; 14:108-123.

Broekmans, F.J., Soules, M.R., Fauser, B.C. Ovarian aging: mechanisms and clinical consequences. Endocr. Rev. 2009; 30: 465-493.

Huhtaniemi, I., Hovatta, O., La Marca, A., Livera, G., Monniaux, D., Persani, L., Heddar, A., Jarzabek, K., Laisk-Podar, T., Salumets, A. Advances in the molecular pathophysiology, genetics, and treatment of primary ovarian insufficiency. Trends in Endocrinology and Metabolism 2018.

Gougeon, A., Ecochard, R., Thalabard, J.C. Age-related changes of the population of human ovarian follicles: increase in the disappearance rate of non-growing and early-growing follicles in aging women. Biol. Reprod. 1994; 50: 653-663.

McLaughlin M., Albertini D.F., Wallace W.H.B., Anderson R.A., Telfer E.E. Metaphase II oocytes from human unilaminar follicles grown in a multistep culture system. Mol. Hum. Reprod. 2018; 24:135-142.

Herraiz S., Buigues A., Díaz-García C., Romeu M., Martínez S., Gómez-Seguí I., Simón C., Hsueh A.J., Pellicer A. Fertility rescue and ovarian follicle growth promotion by bone marrow stem cell infusion. Fertil. Steril. 2018; 109:908 918.

Sills E.S., Rickers N.S., Li X., Palermo G.D. First data on in vitro fertilization and blastocyst formation after intraovarian injection of calcium gluconate-activated autologous platelet rich plasma. Gynecol. Endocrinol. 2018; 34:756-760.

Lee J.W., Kwon O.H., Kim T.K., Cho Y.K., ChoiK.Y., Chung H.Y., Cho B.C., Yang J.D., Shin J.H. Platelet-rich plasma: quantitative assessment of growth factor levels and comparative analysis of activated and inactivated groups. Arch. Plast. Surg. 2013; 40:530-535.

Li, J., Kawamura, K., Cheng, Y., Liu, S., Klein, C., Liu, S., Duan, E.K., Hsueh, A.J. Activation of dormant ovarian follicles to generate mature eggs. Proc. Natl. Acad. Sci. U. S. A. 2010; 107: 10280–10284.

Kawamura, K., Cheng, Y., Suzuki, N., Deguchi, M., Sato, Y., Takae, S., Ho, C.H., Kawamura, N., Tamura, M., Hashimoto, S., Sugishita, Y., Morimoto, Y., Hosoi, Y., Yoshioka, N., Ishizuka, B., Hsueh, A.J. Hippo signaling disruption and Akt stimulation of ovarian follicles for infertility treatment. Proc. Natl. Acad. Sci. U. S. A. 2013; 110: 17474–17479.

Kawamura, K., Ishizuka, B., Hsueh, A.J.W. Drug-free in-vitro activation of follicles for infertility treatment in poor ovarian response patients with decreased ovarian reserve. Reprod. Biomed. 2020; 40: 245-253.

Hsueh, A.J., Kawamura, K., Cheng, Y., Fauser, B.C. Intraovarian control of early folliculogenesis. Endocr. Rev. 2015; 36: 1–24.

Cheng Y., Feng Y., Jansson L., Sato Y., Deguchi M ., Kawamura K., Hsueh A.J. Actin polymerization-enhancing drugs promote ovarian follicle growth mediated by the Hippo signaling effector YAP. FASEB J. 2015; 29:2423-2430.

Grosbois J., Demeestere I. Dynamics of PI3K and Hippo signaling pathways during in vitro human follicle activation. Hum. Reprod. 2018; 33:1705-1714.

Zhai, J., Yao, G., Dong, F., Bu, Z., Cheng, Y., Sato, Y., Hu, L., Zhang, Y., Wang, J., Dai, S., Li, J., Sun, J., Hsueh, A.J., Kawamura, K., Sun, Y. In vitro activation of follicles and fresh tissue auto-transplantation in primary ovarian insufficiency patients. J. Clin. Endocrinol. Metab. 2016; 101: 4405-4412.

Ferraretti, A.P., La Marca, A., Fauser, B.C., Tarlatzis, B., Nargund, G., Gianaroli, L. ESHRE Working Group on Poor Ovarian Response Definition. ESHRE consensus on the definition of ‘poor response’ to ovarian stimulation for in vitro fertilization: the Bologna criteria. Hum. Reprod. 2011; 26:1616-1624.

Kailasam, C., Keay, S., Wilson, P., Ford, W., Jenkins, J. Defining poor ovarian response during ivf cycles, in women aged < 40 years, and its relationship with treatment outcome. Hum. Reprod. 2004; 19: 1544-1547.

Additional Files

Published

2020-12-30

How to Cite

[1]
Girsh Е. , Harlev А. and Grin Л. 2020. In-vitro activation of ovarian follicular residual reserve. Reproductive Medicine (Central Asia). 4 (45) (Dec. 2020), 25–28. DOI:https://doi.org/10.37800/RM2020-1-34.