Interferon status of endometry in patients with miscarriage and “Thin endometry” syndrome

Authors

  • N.M. Mamedalieva
  • A.M. Kurmanova
  • G.Zh. Anartaeva

DOI:

https://doi.org/10.37800/RM2020-1-33

Keywords:

“thin endometry” syndrome, miscarriage, endometrium, cytotoxic endometrial lymphocytes, interferon

Abstract

The article presents the results of examination of 21 patients with miscarriage and “thin endometry” syndrome compared
with 20 patients without reproductive losses and the presence of normal endometrial thickness. Interferon gamma intracellular
production by cytotoxic endometrial lymphocytes was investigated by flow cytofluorometry. Based on the study, it was found
that in patients with miscarriage and “thin endometry” syndrome, the interferon gamma intracellular production by cytotoxic
CD8+ lymphocytes was sharply suppressed by almost 36 times, by CD56+ lymphocytes - by 13 times, by CD16+ lymphocytes
- by 4.5 times.

References

Diejomaoh MF. Recurrent spontaneous miscarriage is still a challenging diagnostic and therapeutic quagmire. Med Princ Pract. 2015;24 Suppl 1:38–55.

Mamedaliyeva N. M., Lokshin V. N., Kurmanova A.M. Comprehensive assessment of immunity and approaches to differentiated immunocorrection in recurrent miscarriage. Gynecol.Endocrinol. 2015;31(51):55-57.

Mamedaliyeva N. M., Kurmanova A.M., Moshkalova G.N., Kim V. Local immunity status in patients with miscarriages and herpetic infection. Gynecol.Endocrinol. 2016;32(sup2):45-46

Seshadri S, Sunkara SK. Natural killer cells in female infertility and recurrent miscarriage: a systematic review and metaanalysis. Hum Reprod Update 2014, May-Jun;20(3):429-38.

Michou VI, Kanavaros P, Athanassiou V, Chronis GB, Stabamas S, Tsilivakos V., (2003). Fraction of the peripheral blood concentration of CD56+/CD16-/CD3- cells in total natural killer cells as an indication of fertility and infertility. Fertil Steril., Sep;80, 2, 691-7

De Maria A, Bozzano F, Cantoni C, Moretta L., (2011). Revisiting human natural killer cell subset function revealed cytolytic CD56 (dim) CD16+ NK cells as rapid producers of abundant IFN-gamma on activation. Proc Natl Acad Sci USA. 108, 728–732.

Крылова Ю.С., Кветной И.М., Айламазян Э.К. Рецептивность эндометрия: молекулярные механизмы регуляции имплантации // Журнал акушерства и женских болезней. – 2013. - №2. – С.63-74.

Сидельникова В.М. Привычная потеря беременности. - 2015, 400 с.

Маринкин И.О., Кулешов В.М, Айдагулова С.В. Новая интерпретация снижения рецептивности эндометрия при привычном невынашивании беременности // Status Praesens, 2013г: 6:23, 74-80

Опрышко В.И., Носивец Д.С Инновации и тренды в клинической фармакологии вагинальных форм гестагенов // Медицинские аспекты здоровья женщин, 2016, 5(102), с 55-60.

Additional Files

Published

2020-12-30

How to Cite

[1]
Mamedalieva Н. , Kurmanova А. and Anartaeva Г. 2020. Interferon status of endometry in patients with miscarriage and “Thin endometry” syndrome. Reproductive Medicine (Central Asia). 4 (45) (Dec. 2020), 29–33. DOI:https://doi.org/10.37800/RM2020-1-33.

Issue

No. 4 (45) (2020): Reproductive medicine

Section

Статьи

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