Modern methodological approaches to the definition of ovarian aromatase in polycystic ovary syndrome
Keywords:
polycystic ovary syndrome, ovarian aromataseAbstract
In order to study ovarian flavor ase activity in polycystic ovary syndrome (PCOS) examined 65 patients with PCOS and 45
healthy women of reproductive age. Aromatase activity determined using estradiol/number of antral follicles in both ovaries
ratio (Е2/п). Values ovarian aromatase positively correlated (p < 0.05) with the results of its determi¬nation by a test with
the aromatase inhibitor letrozole in PCOS. Reduced aromatase activity of antral follicles was present in 59 % of patients with
PCOS. These data indicate that Е2/п ratio allows to evaluate ovarian aromatase and that an absolute or relative deficiency of
ovarian aromatase underlies the pathogenesis of PCOS.
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