Имплантация қайталап сәтсіз болған пациенттердегі созылмалы эндометрит: эпидемиология, этиология, патогенез және бедеулікті жеңу
DOI:
https://doi.org/10.37800/RM2021-2-3Кілт сөздер:
созылмалы эндометрит, имплантацияның қайталанған сәтсіздіктері, цитокинотерапия, репродуктивті нәтижелерАңдатпа
Соңғы жылдардағы деректер сәтті имплантация мен клиникалық жүктіліктің басталуында көптеген басқа танылған факторларға қарағанда эндометрийдің әлдеқайда маңызды рөл атқаратынын көрсетеді. Созылмалы эндометрит (СЭ) имплантацияның қайталанған сәтсіздіктерін қамтитын теріс репродуктивті нәтижелермен байланысты.
Streptococcusspp., Escherichiacoli, Enterococcusfaecalis, Klebsiellapneumoniae, Staphylococcusspp., Corynebacterium және
Mycoplasma / Ureaplasmaspp қазіргі уақытта
СЭ-нің негізгі қоздырғыштары болып саналады. Бұл ауру эндометрийдің сәулетін әртүрлі деңгейлерде бұзады: ең алдымен, СЭ иммун компетентті жасушалар популяциясының өзгеруіне ықпал етеді, демек, имплантация кезінде эндометрийдегі жергілікті иммундық жауаптың бұзылуына ықпал етеді. СЭ-ні антибиотиктермен емдеу имплантация
жиілігін жақсартады және түсік түсіру жиілігін төмендетеді, дегенмен бұл тұжырымды растайтын жоспарланған, келешекке бағытталған зерттеулер жоқ. СЭ антибиотиктермен емдеудің, әсіресе қоздырғыштардың резистенттілігі
жағдайында жеткіліксіз тиімділігін ескере отырып, немесе вирустық созылмалы эндометрит жағдайында СЭ дамуы
мен қолдаудың басқа этиопатогенетикалық жолдарына әсер ететін препараттарды қосымша қолдану схемасын әзірлеу
қажет. Бұндай емдеудің мысалы ретінде СЭ терапиясындағы тиімділік пен қауіпсіздікке қатысты одан әрі зерттеуді талап ететін цитокинотерапия болуы мүмкін.
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Қосымша файлдар
Жарияланды
Дәйексөзді қалай келтіруге болады
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