Evaluation of the impact of vaccination from COVID 19 on the course of the ivf program and its outcomes
DOI:
https://doi.org/10.37800/RM.2.2022.7-13Keywords:
assisted reproductive technologies, covid-19, intracytoplasmic injection, in-vitro fertilization, vaccinationAbstract
Relevance: Regarding the COVID-19 pandemic that began in 2020, the issue of the impact of the disease on a woman's fertility continues to be debatable in the medical reproductive community. Since the development of vaccines, misinformation has arisen regarding the negative impact of vaccination on a woman's reproductive function. Despite the existence of scientific evidence that refutes this hypothesis, further research is needed on the effect of the Sputnik V vaccine on a woman's reproductive potential.
The purpose of the study was to evaluate the impact of the use of the Sputnik V vaccine on the course of IVF/ICSI programs and its outcomes in patients of the Institute of Reproductive Medicine, Almaty, Kazakhstan.
Methods: 1350 records of patients who underwent ART cycles from 2020 to 2021 were reviewed. The selected patients were divided into two groups: patients who were vaccinated before the IVF/ICSI program (group I, studygroup) and patients who did not use the vaccine (group II, control group). The groups were further divided into 2 age categories: ≤35 and >35.
The results of the study showed no difference in the number of received oocytes and mature oocytes between the two groups in both age categories. No significant difference was found in the average number of received blastocysts between the control group and the study group (≤35: group I - 4.3, group II - 3.9; >35: group I - 2.2, group II - 2.0). Similarly, the analysis of clinical pregnancy rate (CPR) did not demonstrate a statistically significant difference (p>0.05). in the category of women under 35 years old and amounted to 48.4% (n=162) and 47.6% (n=263) in the study group (I) and control group (II), respectively. In the comparison groups of vaccinated (I) and non-vaccinated (II) women over 35 years of age, CPR was 36.3% (n=55) and 34.4% (n=162), respectively (p>0.05).
Conclusion: the use of the Sputnik V vaccine against SARS-CoV-2 by female patients did not have a significant impact on the clinical and embryological indicators of the effectiveness of ART programs.
References
Гриднев О.В., Муравьёв С.М. Участие Минздрава России в мероприятиях по профилактике и борьбе с новой коронавирусной инфекцией, организуемых в зарубежных государствах // Вестник Рос. Здрав. надзора. – 2020. – №.4. – С. 15-22. [Gridnev O.V., Muravyev S.M. Uchastie Minzdrava Rossii v meropriyatiyah po profilaktike I borbe s novoy koronovirusnoy infectsiyei, organizuemyh v zarubezhnyh gosudarstvah // Vestnik Ros. Zdrav. Nadzora – 2020. – №.4. – S. 15-22. (in Russ).]. https://doi.org/10.35576/2070-7940-2020-4-15-22.
WHO COVID-19 Dashboard. Geneva: World Health Organization. – 2020. https://covid19.who.int/.
Hannah R., Mathieu E., Rodés-Guirao L., Appel C., Giattino Ch., Ortiz-Ospina E., Hasell J., Macdonald B., Beltekian D., Roser M. Coronavirus pandemic (COVID-19) // Our world in data. – 2020. https://ourworldindata.org/covid-vaccinations?country=JPN~USA.
Mostaured Ali K., Khan N., Mustagir G., Rana J., Haque R., Rahman M. COVID-19 infection during pregnancy: asystematic review to summarize possible symptoms, treatments, and pregnancy outcomes // Med. Rxiv. – 2020. https://doi.org/10.1101/2020.03.31.20049304.
Ortiz E.I., Herrera E., De La Torre A. Coronavirus (COVID 19) infection in pregnancy // Colombia Médica. – 2020. – Vol. 2(51). https://doi.org/10.25100/cm.v51i2.4271.
Morris R. S. SARS-CoV-2 spike protein seropositivity from vaccination or infection does not cause sterility // Reports. – 2021. – Vol. 3(2). – P. 253-255. https://doi.org/10.1016/j.xfre.2021.05.010.
Jean-Louis F., Olivier D., Cheynet V., Blond J.L., Bouton O., Vidaud M., Rabreau M., Evain-Brion D., Mallet F. Direct involvement of HERV-W Env. Glycoprotein in human trophoblast cell fusion anddifferentiation //Molecular and cellular biology. – 2003. – Vol. 10(23). – P. 3566-3574. https://doi.org/10.1128/MCB.23.10.3566-3574.2003.
Morris R.S. SARS-CoV-2 spike protein seropositivity from vaccination or infection does not cause sterility // Reports. – 2021. – Vol. 3(2). – P. 253-255. https://doi.org/10.1016/j.xfre.2021.05.010.
Devora A., Lederman M., Ghofranian A., Hernandez-Nieto C., Canon C., Hanley W., Gounko D. et al. In vitro fertilization and earlypregnancy outcomes after coronavirus disease 2019 (COVID-19) vaccination // Obstetrics & Gynecology. – 2022. – Vol. 4(139). – P. 490-497. https://doi.org/10.1097/AOG.0000000000004713.
Fei Ch., Zhu Sh., Dai Zh., Hao L., Luan Ch., Guo Q., Meng Ch., Zhang Y.Effects of COVID-19 and mRNA vaccines on humanfertility // Human Reproduction. – 2022. – Vol. 1(37). – P. 5-13. https://doi.org/10.1093/humrep/deab238.
Shu Qin W., Bilodeau-Bertrand M., Shiliang Liu Sh., Auger N. Increased pregnancy problems with COVID-19–meta-analysis and letter to editor // CMAJ. – 2021. – Vol. 16 (193). – P. E540-E548. https://doi.org/10.1503/cmaj.202604.
Lu-Culligan A., Iwasaki A. The false rumors about vaccines that are scaring women // New York Times. – 2021. –Vol. 26. https://www.nytimes.com/2021/01/26/opinion/covid-vaccine-rumors.html.
Schaler L., Wingfield M. COVID-19 vaccine - can it affect fertility? // Irish Journal of Medical Science (1971). – 2021. – P. 1-3. https://doi.org/10.1007/s11845-021-02807-9.
Magnusson Å., Källen K., Thurin-Kjellberg A., Bergh C. The number of oocytes retrieved during IVF: a balance between efficacy and safety // Human reproduction. – 2018. – Vol. 1(33). – P. 58-64. https://doi.org/10.1093/humrep/dex334.
Orvieto R., Noach-Hirsh M., Segev-Zahav A., Haas J., Nahum R., Aizer A. Does mRNASARS-CoV-2 vaccine influence patients' performance during IVF-ET cycle? // Reproductive Biology and Endocrinology. – 2021. – Vol. 1(19). – P. 1-4. https://doi.org/10.1186/s12958-021-00757-6.
Downloads
Published
How to Cite
Issue
Section
License
The articles published in this Journal are licensed under the CC BY-NC-ND 4.0 (Creative Commons Attribution – Non-Commercial – No Derivatives 4.0 International) license, which provides for their non-commercial use only. Under this license, users have the right to copy and distribute the material in copyright but are not permitted to modify or use it for commercial purposes. Full details on the licensing are available at https://creativecommons.org/licenses/by-nc-nd/4.0/.
