Medical and social factors of infertility and their impact on the effectiveness of infertility treatment using high-tech treatment methods
DOI:
https://doi.org/10.37800/RM.3.2022.40-46Keywords:
infertility factors, assisted reproductive technologies, quota programs, high-tech treatment methodsAbstract
Relevance: Last years, due to the use of high-tech infertility treatments, many previously insurmountable infertility factors have lost their importance.
The study aimed to establish the etiological structure of infertility in the Aktobe Region and to assess the risk factors for reproductive dysfunction and their impact on the effectiveness of infertility treatment using high-tech treatment methods.
Methods: We analyzed the medical records, counseling data, and effectiveness of IVF programs on January 1, 2022, of 324 infertile couples living in the Aktobe Region and treated for infertility under a quota in 2021.
Results: We chose 23 factors from anamnestic-clinical data and studied their possible impact on the effectiveness of high-tech infertility treatment methods. The following groups of factors that influence the effectiveness of treatment of infertility using high-tech treatment methods have been identified: “Age groups,” “Primary/Secondary infertility,” “Factors of infertility under ICD N97.0-N97.9,” “Antimuller hormone (AMH) level.” The decrease in IVF effectiveness with age is well-known and confirmed by this study's results. According to the effects of logistic regression, the factor “secondary infertility” (OSH=1.860{95% 1.160-2.982}) increases the possibility of not getting pregnant by 1.86 times due to endometrial changes. Among “Infertility factors, according to ICD N97.0-N97.9, the lowest efficiency is noted at “unknown factor infertility N97.9” – 16.6%, which doubles the possibility of not getting pregnant.
The result of “AMH below 1 with follicle-stimulating hormone (FSH) below 12 and the presence of at least six antral follicles” showed a high efficiency of treatment – 61.5%, due to donor cells in this category of patients.
Conclusion: In the treatment of infertility by quota programs, the most significant factors that reduce the effectiveness are age, secondary infertility (with a history of uterine pregnancy), as well as “unidentified infertility factor N97.9,” indirectly indicating the importance of identifying possible disorders on the genetic and psychological levels.
References
Кузьмин В.Н., Машина М.А. Оптимизация специализированной медицинской помощи при бесплодии // Лечащий врач. – 2017. – №3. – С. 38 [Kuz’min V.N., Mashina M.A. Optimizaciya specializirovannoj medicinskoj pomoshhi pri besplodii // Lechashhij vrach. – 2017. – №3. – S. 38. (in Russ.)]. https://www.lvrach.ru/2017/03/15436685
Чигринец С. В. Эндокринные дизрапторы и бесплодие / С. В. Чигринец, Г. В. Брюхин. - Челябинск : Титул, 2020. - 190 c. – ISBN 9785604182444 [Chigrinec S. V. E’ndokrinnye dizraptory i besplodie / S. V. Chigrinec, G. V. Bryuxin. - Chelyabinsk : Titul, 2020. - 190 c. – ISBN 9785604182444. (in Russ.)]. https://www.books-up.ru/ru/book/endokrinnye-dizraptory-i-besplodie-11019695/
Бесплодие в браке : учебное пособие / Н. А. Линченко, М. В. Андреева, С. В. Копань и др. - Волгоград : ВолгГМУ, 2021. - 68 c. - ISBN 9785965206803 [Besplodie v brake : uchebnoe posobie / N. A. Linchenko, M. V. Andreeva, S. V. Kopan’ i dr. - Volgograd : VolgGMU, 2021. - 68 c. - ISBN 9785965206803 (in Russ.)]. https://www.books-up.ru/en/book/besplodie-v-brake-13833522/
Ходжимуродова Д.А., Гулакова Д.М., Ошурмамадова Р.Б., Бойматова З.К. Современная инновационная технология в диагностике женского бесплодия // Мать и дитя. – 2020. – №2. – С. 27-31 [Xodzhimurodova D.A., Gulakova D.M., Oshurmamadova R.B., Bojmatova Z.K. Sovremennaya innovacionnaya texnologiya v diagnostike zhenskogo besplodiya // Mat’ i ditya. – 2020. – №2. – S. 27-31 (in Russ.)]. https://www.elibrary.ru/item.asp?id=48201817
Асадова Г.А. Актуальные проблемы бесплодия у женщин // Recent scientific investigation: proceedings of XXIII International Multidisciplinary Conference. Shawnee, USA. – 2021. – С.15-19 [Asadova G.A. Aktual’nye problemy besplodiya u zhenshhin // Recent scientific investigation: proceedings of XXIII International Multidisciplinary Conference. Shawnee, USA. – 2021. – S.15-19 (in Russ.)]. https://www.elibrary.ru/item.asp?id=46463193
Оразов М.Р., Радзинский В.Е., Хамошина М.Б., Михалева Л.М., Волкова С.В., Абитова М.З. Причины эндометриоз-ассоциированного бесплодия // Репродуктивная медицина. – 2020. – №2(43). – С. 43-48 [Orazov M.R., Radzinskij V.E., Xamoshina M.B., Mixaleva L.M., Volkova S.V., Abitova M.Z. Prichiny e’ndometrioz-associirovannogo besplodiya // Reproduktivnaya medicina. – 2020. – №2(43). – S. 43-48 (in Russ.)]. https://doi.org/10.37800/RM2020-1-17
Оразов М.Р., Радзинский В.Е., М.Б. Хамошина, Волкова С.В., Абитова М.З., Шустова В.Б. Эндометриальный фактор эндометриоз-ассоциированного бесплодия // Репродуктивная медицина. – 2020. – №3(44). – С. 28-38 [Orazov M.R., Radzinskij V.E., M.B. Xamoshina, Volkova S.V.,
Abitova M.Z., Shustova V.B. E’ndometrial’nyj faktor e’ndometrioz-associirovannogo besplodiya // Reproduktivnaya medicina. – 2020. – №3(44). – S. 28-38 (in Russ.)]. https://doi.org/10.37800/RM2020-1-22
Девятова Е.А., Вартанян Э.В., Цатурова К.А., Девятов И.М. Эндометриопатии и бесплодие // Репродуктивная медицина. – 2022. – №1(50). – С. 60-67 [Devyatova E.A., Vartanyan E’.V., Caturova K.A., Devyatov I.M. E’ndometriopatii i besplodie // Reproduktivnaya medicina. – 2022. – №1(50). – S. 60-67 (in Russ.)]. https://doi.org/10.37800/RM.1.2022.60-67
Тойчиева Г.К., Оралхан Ж., Аленова А.А., Саханова С.К., Бердалинова А.К., Журабекова Г.А. Исследование взаимосвязи показателей овариального резерва и влияния факторов образа жизни при первичном бесплодии // Репродуктивная медицина. – 2022. – №3(52). – С. 34-40 [Tojchieva G.K., Oralxan Zh., Alenova A.A., Saxanova S.K., Berdalinova A.K., Zhurabekova G.A. Issledovanie vzaimosvyazi pokazatelej ovarial’nogo rezerva i vliyaniya faktorov obraza zhizni pri pervichnom besplodii // Reproduktivnaya medicina. – 2022. – №3(52). – S. 34-40 (in Russ.)]. https://doi.org/10.37800/RM.3.2022.34-40
Downloads
Published
How to Cite
Issue
Section
License
The articles published in this Journal are licensed under the CC BY-NC-ND 4.0 (Creative Commons Attribution – Non-Commercial – No Derivatives 4.0 International) license, which provides for their non-commercial use only. Under this license, users have the right to copy and distribute the material in copyright but are not permitted to modify or use it for commercial purposes. Full details on the licensing are available at https://creativecommons.org/licenses/by-nc-nd/4.0/.
