Live birth of a genetically own child in a couple, where the male partner is diagnosed with reciprocal translocation

Abstract

Relevance: The presented clinical case describes treatment tactics that enabled the birth of a genetically own child in a married couple with complex anamnesis.
The purpose was to demonstrate successful pregnancy and live birth of genetically own and healthy child in a couple, where the male partner was diagnosed with reciprocal translocation in the karyotype.
Methods: The paper describes a modification of the treatment used in the two previous stimulation protocols. In particular, the superovulation was stimulated by recombinant follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Each IVF program included preimplantation genetic testing for aneuploidy (PGT-A). In total, ten blastocysts were sent for genetic testing.
Results: This clinical case demonstrates a successful pregnancy and live birth of a genetically own child in the stimulation
protocols with recombinant FSH and LH. Through karyotyping, the male partner was diagnosed with reciprocal translocation between 6 and 11 chromosomes. Over three IVF attempts, we received ten blastocysts eligible for biopsy and genetic testing. PGT-A approved two blastocysts for the transfer in controlled ovarian stimulations with FSH and LH. The 2nd frozen embryo replacement was successful.
Conclusion: For some normogonadotropic women, combining the recombinant FSH with recombinant LH is an optimal strategy to obtain euploid embryos.