Medical care for postpartum bleeding: A literature review

Authors

  • S.Sh. Issenova
  • D.B. Beisenova KazNMU
  • A.B. Yeshim
  • G.Y. Zhanabatyrova
  • M.S. Akynbay
  • G.K. Yermakhanbet
  • A.A. Kadyrova

DOI:

https://doi.org/10.37800/RM.1.2023.50-56

Keywords:

postpartum hemorrhage (PPH), cesarean section (C-section), uterine atony, uterine rupture, uterine trauma, coagulopathy, placental pathology

Abstract

Relevance: According to modern literature, over the past decade, there has been no tendency in the world to reduce maternal mortality from postpartum hemorrhage (PPH). In Kazakhstan, evidence-based medicine clinical recommendations on prevention and algorithm of action for obstetric bleeding have been developed and recommended for use since 2010. We conducted a literary search for existing innovative methods of PPH prevention and treatment based on the study of clinical recommendations of many developed countries, WHO, FIGO, and scientific publications. There exist separate algorithms for managing PPH during vaginal delivery or cesarean section.
The study aimed to explore the existing innovative methods of preventing and treating postpartum hemorrhage to determine the most effective medical care for postpartum hemorrhage.
Materials and methods: The literature search included papers published on PubMed in English from January 1, 2018, to November 31, 2022. The search was done by keywords including “pregnancy,” “PPH,” “pregnancy complication,” “pregnancy outcomes,” and “tranexamic acid,” “guideline.”

Results: Today, there are separate algorithms for managing PPH during vaginal delivery or cesarean section. Fibrin preparations and fibrinogen concentrate are recommended for use. When PPH occurs, it is important to communicate with family members to further inform them about the patient’s condition. The routine use of the Allgower shock index for accurate calculation of the volume of blood loss is proposed. It is proposed to use antifibrinolytic drugs not only for therapeutic purposes but also for prophylactic purposes. It is important to carry out adequate infusion-transfusion therapy to prevent iatrogenic coagulopathy.
Conclusion: Introducing the above modern technologies into practical healthcare does not require high economic costs and can be used in obstetric institutions at all levels of medical care for PPH.

References

Oglak S.C., Obut M., Tahaoglu A.E., Demirel N.U., Kahveci B., Bagli I. A prospective cohort study of shock index as a reliable marker to predict the patient’s need for blood transfusion due to postpartum hemorrhage // Pak. J. Med. Sci. – 2021. – Vol. 37(3). – P. 863-868. https://pubmed.ncbi.nlm.nih.gov/34104179/

Lagrew D, McNulty J, Sakowski C, Cape V, McCormick E, Morton CH. Improving Health Care Response to Obstetric Hemorrhage, a California Maternal Quality Care Collaborative Toolkit, 2022. https://www.cmqcc.org/sites/default/files/HEMToolkit_03252022%20Errata%207.2022%20(2).pdf

Makino Y., Miyak K., Okada A., Ikeda Y., Okada Y. Predictive accuracy of the shock index for severe postpartum hemorrhage in high-income countries: A systematic review and meta-analysis // J. Obstet. Gynaecol. Res. – 2022. – Vol. 48. – P. 2027-2037. https://obgyn.onlinelibrary.wiley.com/doi/10.1111/jog.15292

Nathan H.L., Seed P.T., Hezelgrave N.L., De Greeff A., Lawley E., Anthony J., Steyn W., Hall D.R., Chappell L.C., Shennan A.H. Shock index thresholds to predict adverse outcomes in maternal hemorrhage and sepsis: A prospective cohort study // Acta Obstet. Gynecol. Scand. – 2019. – Vol. 98(9). – P. 1178-1186. https://pubmed.ncbi.nlm.nih.gov/31001814/

Tanacan A., Fadiloglu E., Unal C., Beksac M.S. Importance of shock index in the evaluation of postpartum hemorrhage cases that necessitate blood transfusion // Women Health. – 2020. – Vol. 60(9). – P. 1070-1078. https://pubmed.ncbi.nlm.nih.gov/32757719/

Pacagnella R.C., Borovac-Pinheiro A. Assessing and managing hypovolemic shock in puerperal women // Best Pract. Res. Clin. Obstet. Gynaecol. – 2019. – Vol. 61. – P. 89-105. https://pubmed.ncbi.nlm.nih.gov/31345740/

Lee S.Y., Kim H.Y., Cho G.J., Hong S.C., Oh M.J., Kim H.J. Use of the shock index to predict maternal outcomes in women referred for postpartum hemorrhage // Int. J. Gynaecol. Obstet. – 2019. – Vol. 144(2). – P. 221-224. https://pubmed.ncbi.nlm.nih.gov/30447073/

Takeda S., Makino S., Takeda J., Kanayama N., Kubo T., Nakai A., Suzuki S., Seki H., Terui K., Inaba S., Miyata S. Japanese Clinical Practice Guide for Critical Obstetrical Hemorrhage (2017 revision) // J. Obstet. Gynaecol. Res. – 2017. – Vol. 43(10). – P. 1517-1521. https://pubmed.ncbi.nlm.nih.gov/28737252/

Республиканский центр развития здравоохранения МЗ РК. Послеродовое кровотечение. Версия: Клинические про-токолы МЗ РК – 2016: одобр. Объединенной комиссией по качеству медицинских услуг МЗСР РК от 8 декабря 2016 г., Протокол № 17 [Republican Center for Health Development of the Ministry of Healthcare of the Republic of Kazakhstan. Postpartum hemorrhage. Version: Clinical Protocols of the Ministry of Healthcare of the Republic of Kazakhstan - 2016: appr. Joint Commission on the Quality of Medical Services of the MHSD of the Republic of Kazakhstan dated December 8, 2016, Protocol No. 17 (in Russ.)]. https://diseases.medelement.com/disease/послеродовое-кровотечение-кп-рк-2023/17536

Al-Farabi Kazakh National UniversityMavrides E., Allard S., Chandraharan E., Collins P., Green L., Hunt B.J., Riris S., Thomson A.J. on behalf of the Royal College of Obstetricians and Gynaecologists. Prevention and Management of Postpartum Haemorrhage // BJOG. – 2016. – Vol. 124. – P. e106-e149. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8077797/

Queensland Clinical Guidelines. Postpartum hemorrhage. – Guideline No. MN18.1-V10-R23. – Queensland Health, 2021. https://www.health.qld.gov.au/__data/assets/pdf_file/0015/140136/g-pph.pdf

World Health Organization (WHO). Updated WHO Recommendation on TXA for the Treatment of Postpartum Haemorrhage. – Geneva, Switzerland: WHO, 2017. https://apps.who.int/iris/bitstream/handle/10665/259374/9789241550154-eng.pdf

Ministry of Health. National Consensus Guideline for Treatment of Postpartum Haemorrhage. – Wellington: Ministry of Health, 2022. https://www.health.govt.nz/system/files/documents/publications/national-consensus-guideline-for-treatment-of-postpartum-haemorrhage-mar22.pdf. 20.03.2023

Escobar M.F., Nassar A.H., Theron G., Barnea E.R., Nicholson W., Ramasauskaite D., Lloyd I., Chandraharan E., Miller S., Burke T., Ossanan G., Andres Carvajal J., Ramos I., Hincapie M.A., Loaiza S., Nasner D.; FIGO Safe Motherhood and Newborn Health Committee. FIGO recommendations on the management of postpartum hemorrhage 2022 // Int. J. Gynaecol. Obstet. – 2022. – Vol. 157 (Suppl. 1). – P. 3-50. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843767/

Sentilhes L., Daniel V., Deneux-Tharaux C.; TRAAP2 Study Group and the Groupe de Recherche en Obstétrique et Gynécologie (GROG). TRAAP2 – TXA for Preventing postpartum hemorrhage after cesarean delivery: a multicenter randomized, double-blind, placebo-controlled trial – a study protocol // BMC Pregnancy Childbirth. – 2020. – Vol. 20(1). – P. 63. https://pubmed.ncbi.nlm.nih.gov/32005192/

Della Corte L., Saccone G., Locci M., Carbone L., Raffone A., Giampaolino P., Ciardulli A., Berghella V., Zullo F. TXA for treatment of primary postpartum hemorrhage after vaginal delivery: a systematic review and meta-analysis of randomized controlled trials // J. Matern. Fetal. Neonatal. Med. – 2020. – Vol. 33(5). – P. 869-874. https://pubmed.ncbi.nlm.nih.gov/30122082/

Saccone G., Della Corte L., D’Alessandro P., Ardino B., Carbone L., Raffone A., Guida M. Locci M., Zullo F., Berghella V. Prophylactic use of TXA after vaginal delivery reduces the risk of primary postpartum hemorrhage // J. Matern. Fetal Neonatal. Med. – 2020. – Vol. 33 (19). – P. 3368-3376. https://www.tandfonline.com/doi/full/10.1080/14767058.2019.1571576?af=R

Xia Y., Griffiths B.B., Xue Q. TXA for postpartum hemorrhage prevention in vaginal delivery: A meta-analysis // Medicine (Baltimore). – 2020. – Vol. 99(3). – Art. no. e18792. https://pubmed.ncbi.nlm.nih.gov/32011478/

Kashanian M., Dadkhah F., Tabatabaei N., Sheikhansari N. Effects of TXA on the amount of bleeding following vaginal delivery and its adverse effects: a double-blind placebo-controlled randomized clinical trial // J. Matern. Fetal. Neonatal. Med. – 2022. – Vol. 35(25). – P. 5611-5615. https://pubmed.ncbi.nlm.nih.gov/34024233/

Sentilhes L., Sénat M.V., Le Lous M., Winer N., Rozenberg P., Kayem G., Verspyck E., Fuchs F., Azria E., Gallot D., Korb D., Desbrière R., Le Ray C., Chauleur C., de Marcillac F., Perrotin F., Parant O., Salomon L.J., Gauchotte E., Bretelle F.., Sananès N, Bohec C., Mottet N., Legendre G., Letouzey V., Haddad B., Vardon D., Madar H., Mattuizzi A., Daniel V., Regueme S., Roussillon C., Benard A., Georget A., Darsonval A., Deneux-Tharaux C.; Groupe de Recherche en Obstétrique et Gynécologie. TXA for the Prevention of Blood Loss after Cesarean Delivery // N. Engl. J. Med. – 2021. – Vol. 384(17). – P. 1623-1634. https://www.fhu-prema.org/publications/tranexamic-acid-for-the-prevention-of-blood-loss-after-cesarean-among-women-with-twins-a-secondary-analysis-of-the-tranexamic-acid-for-preventing-postpartum-hemorrhage-following-a-cesarean-delivery-r/

Iqbal M.J., Mazhar A., Shabir A. Intravenous TXA versus placebo during Caesarian section: A comparative study // Pak. J. Med. Sci. – 2022. – Vol. 38(5). – P. 1183-1187. https://pubmed.ncbi.nlm.nih.gov/35799760/

Naeiji Z., Delshadiyan N., Saleh S., Moridi A., Rahmati N., Fathi M. Prophylactic use of TXA for decreasing the blood loss in elective C-section: A placebo-controlled randomized clinical trial // J. Gynecol. Obstet. Hum. Reprod. – 2021. – Vol. 50(1). – Art. no. 101973. https://pubmed.ncbi.nlm.nih.gov/33221559/

Bellos I., Pergialiotis V. TXA for the prevention of postpartum hemorrhage in women undergoing cesarean delivery: an updated meta-analysis // Am. J. Obstet. Gynecol. – 2022. – Vol. 226(4). – P. 510-523.e22. https://www.binasss.sa.cr/abr22/6.pdf

WOMAN Trial Collaborators. Effect of early TXA administration on mortality, hysterectomy, and other morbidities in women with postpartum hemorrhage (WOMAN): an international, randomized, double-blind, placebo-controlled trial // Lancet. – 2017. – Vol. 389(10084). – P. 2105-2116. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)30638-4/fulltext

Lier H., von Heymann C., Korte W., Schlembach D. Peripartum Haemorrhage: Haemostatic Aspects of the New German PPH Guideline // Transfus. Med. Chemother. – 2018. – Vol. 45(2). – P. 127-135. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939659/

Gillissen A., van den Akker T., Caram-Deelder C., Henriquez D.D.C.A., Bloemenkamp K.W.M., van Roosmalen J.J.M., Eikenboom J., van der Bom J.G.; TeMpOH-1 study group. Association between fluid management and dilutional coagulopathy in severe postpartum hemorrhage: a nationwide retrospective cohort study // BMC Pregnancy Childbirth. – 2018. – Vol. 18(1). – Art. no. 398. https://europepmc.org/article/med/30266818

Government of Western Australia. WA Country Health Service. Primary Postpartum Haemorrhage Guideline. Rev.: July 2019 // www.wacountry.health.wa.gov.au/~/media/WACHS/Documents/About. 20.03.2023.

Downloads

Published

2023-03-31

How to Cite

[1]
Issenova , S., Beisenova, D. , Yeshim , A., Zhanabatyrova, G., Akynbay , M., Yermakhanbet , G. and Kadyrova, A. 2023. Medical care for postpartum bleeding: A literature review. Reproductive Medicine (Central Asia). 1(54) (Mar. 2023), 50–56. DOI:https://doi.org/10.37800/RM.1.2023.50-56.