Features of pregnancy course and management after in vitro fertilization

Authors

  • S.Sh. Isenova
  • N.A. Tileukul Казахский национальный медицинский университет им. С.Д. Асфендиярова
  • A.S. Aripkhanova
  • A.M. Boran
  • N.O. Makulbekova

DOI:

https://doi.org/10.37800/RM.2.2023.17-24

Keywords:

in vitro fertilization (IVF), Infertility, additional reproductive technologies (ART), placenta previa, progesterone support, premature birth, thrombophilia

Abstract

Relevance: Infertility is a global public health problem. The prevalence of infertile marriages in the world is 12-15%,
including 10.9% in Western Europe, 14.2% in the US, 17.4% in Russia, and 15% in Kazakhstan, and there is no downward trend. Every year 2-2.5 million new cases of male and female infertility are registered worldwide. IVF can predispose the mother to increased risks and complications during pregnancy. The European Society for Human Reproduction and Embryology (ESHRE) reports that the most important indicator of the success of ART treatment is the birth of one healthy child.
The study aimed to study the features of the course of pregnancy and aspects of antenatal follow-up after IVF.
Materials and methods: With PubMed, Medline, Cochrane Library, LILACS, WHO, Scopus, and Web of Science, a
literature review has been done over five years. The International Center for Clinical Reproductology “PERSONA” conducted a retrospective analysis of the records of the history of childbirth of 450 women after IVF who were registered for pregnancy from 9 weeks. Pregnant women were selected from 2018 to 2022 using a simple random sampling method. Group 1 (N=300) – single-fetal pregnancy after IVF. Group 2 (N=150) - spontaneous single-fetal pregnancy.
Results: In the main group were significantly more common: thrombophilia of various genesis (8% vs. 3%), chronic arterial hypertension (27% vs. 13%), and isthmic-cervical insufficiency, and therefore surgical correction of the cervix was performed (33%). In the IVF group, in 80% of cases, long-term progesterone support was carried out. The main group used antiviral and antibacterial drugs twice more often.
Conclusion: Pregnant women after IVF are a special group of patients with a particularly burdened obstetric and gynecological history. Pregnant women with a history of infertility and after IVF should be classified as a high-risk group for the development of pregnancy complications such as low placentation, hypertensive conditions, isthmic-cervical insufficiency, and premature birth.

References

Тювина Н.А., Николаевская А.О. Бесплодие и психические расстройства у женщин. Сообщение 1 // Неврология, нейропсихиатрия, психосоматика. – 2019. – Т. 11, №4. – С. 117-124 [Tyuvina N.A., Nikolaevskaya A.O. Besplodie i psixicheskie rasstrojstva u zhenshhin. Soobshhenie 1 // Nevrologiya, nejropsixiatriya, psixosomatika. – 2019. – T. 11, №4. – S. 117-124 (in Russ.)]. https://doi.org/10.14412/2074-2711-2019-4-117-124

Raad G., Azouri J., Rizk K., Zeidan N.S., Azouri J., Grandjean V., Hazzouri M. Adverse effects of paternal obesity on the motile spermatozoa quality // PLoS One. – 2019, Feb. 11. https://doi.org/10.1371/journal.pone.0211837

Подзолкова Н.М., Скворцова М.Ю., Прилуцкая С.Г. Беременность после ЭКО: факторы риска развития акушерских осложнений // Пробл. Репрод.. – 2020. – №26(2). – С. 120 131 [Podzolkova N.M., Skvorcova M.Yu., Priluckaya S.G. Beremennost’ posle E’KO: faktory riska razvitiya akusherskix oslozhnenij // Probl. Reprod. – 2020. – №26(2). – S. 120-131 (in Russ.)]. https://doi.org/10.17116/repro202026021120

Vermey B.G., Buchanan A., Chambers G.M., Kolibianakis E.M., Bosdou J., Chapman M.G., CA Venetis. Are Singleton Pregnancies After Assisted Reproduction Technology (ART) Associated With a Higher Risk of Placental Anomalies Compared With Non-ART Singleton Pregnancies? A Systematic Review and Meta-Analysis // BJOG. – 2019. – Vol. 126. – P. 209-218. https://doi.org/10.1111/1471-0528.15227

Локшин В.Н., Джусубалиева Т.М. Клиническая практика в репродуктивной медицине. – Алматы: МедМедиа Казахстан, 2015 [Lokshin V.N., Dzhusubalieva T.M. Klinicheskaya praktika v reproduktivnoi medicine. – Almaty: MedMedia Kazakhstan, 2015 (in Russ.)]. – ISBN 978-601-80151-6-8.

Исенова С.Ш., Бодыков Г.Ж., Ким В.Д., Каргабаева Ж.А., Казыбаева А.С., Кабыл Б.К. Анализ особенностей течения беременности и родов у пациенток с бесплодием в анамнезе после применения программ вспомогательных репродуктивных технологий (ВРТ) // Репрод. мед. – 2019. – №3(40). – С. 45-49 [Isenova S.Sh., Bodykov G.Zh., Kim V.D., Kargabaeva Zh.A., Kazybaeva A.S., Kabyl B.K. Analiz osobennostei techeniya beremennosti i rodov u pacientok s besplodiem v anamneze posle primeneniya programm vspomagatelnih reproduktivnih tehnologii (VRT) // Reprod. med. – 2019. – №3(40). – C. 45-49 (in Russ.)]. https://repromed.kz/index.php/journal/article/view/111

Локшин В., Сулейменова М., Карибаева Ш., Джусубалиева Т., Байкошкарова С., Отарбаев М., Ахметова А., Покотило Л., Макишева А., Тарарака К., Тарарака С., Чалова Л., Ким В., Молбаев А., Имтосими Д., Лапина Е. Вспомогательные репродуктивные технологии в Казахстане за 2019 год: данные национального регистра // Репрод. Мед. – 2022. – №3(52). – С. 7-14. https://doi.org/10.37800/RM.3.2022.7-14

Farquhar C., Marjoribanks J. Assisted Reproductive Technology: An Overview of Cochrane Reviews // Cochrane Database Syst. Rev. – 2018. – Issue 8. https://doi.org/10.1002/14651858.CD010537.pub5

American College of Obstetricians and Gynecologists. Low-Dose Aspirin Use for the Prevention of Preeclampsia and Related Morbidity and Mortality – Practice advisory. – Dec. 2021. https://www.acog.org/clinical/clinical-guidance/practiceadvisory/articles/2021/12/low-dose-aspirin-use-for-the-prevention-of-preeclampsia-and-related-morbidity-and-mortality

Аржанова О.Н., Рулева А.В., Пайкачева Ю.М., Иванова А.О., Ничипорук Н.Г. Риск развития гестационного сахарного диабета у пациенток после использования вспомогательных репродуктивных технологий // Ж. Акуш. и Жен. Болезн. – 2019. – Т. 68, №2. – C. 17-22 [Arzhanova O.N., Ruleva A.V., Pajkacheva Yu.M., Ivanova A.O., Nichiporuk N.G. Risk razvitiya gestacionnogo saxarnogo diabeta u pacientok posle ispol’zovaniya vspomogatel’nyx reproduktivnyx texnologij // Zh. Akush. i Zhen. Bolezn. – 2019. – T. 68, №2. – C. 17-22 (in Russ.)]. https://doi.org/10.17816/JOWD68217-22

Капустина М.В., Петрухин В.А., Бурумкулова Ф.Ф., Долгиева Л.У., Лукашенко С.Ю. Экстракорпоральное оплодотворение и гестационный сахарный диабет: новая проблема // Росс. вестник акуш.-гинекол. – 2011. – №11(1). – С. 73 76 [Kapustina M.V., Petruxin V.A., Burumkulova F.F., Dolgieva L.U., Lukashenko S.Yu. E’kstrakorporal’noe oplodotvorenie i gestacionnyj saxarnyj diabet: novaya problema // Ross. vestnik akush.-ginekol. – 2011. – №11(1). – S. 73-76 (in Russ.)]. https://www.mediasphera.ru/issues/rossijskij-vestnik-akushera-ginekologa/2011/1/031726-61222011116

Smith A.D., Tilling K., Lawlor D.A., Nelson S.M. External validation and calibration of IVF predict: a national prospective cohort study of 130,960 in vitro fertilisation cycles // PLoS One. – 2015. – Vol. 10. – P. e0121357. https://doi.org/10.1371/journal.pone.0121357

Исенова С.Ш., Датхаева З.А., Сагандыкова Н.М., Шаймерденова Г.Г., Сералиева У.С. Влияние индекса массы тела на течение беременности и родов // Вестник КазНМУ. – 2015. – №1. – С. 11-14 [Isenova S.Sh., Datxaeva Z.A., Sagandykova N.M., Shajmerdenova G.G., Seralieva U.S. Vliyanie indeksa massy tela na techenie beremennosti i rodov // Vestnik KazNMU. – 2015. – №1. – S. 11-14 (in Russ.)]. https://cyberleninka.ru/article/n/vliyanie-indeksa-massy-tela-natechenie-beremennosti-i-rodov

Камилова Д.П., Якунина Н.А., Кетиладзе Т.М. Поддержка лютеиновой фазы как один из ключевых факторов повышения эффективности вспомогательных репродуктивных технологий // Пробл. Репрод.. – 2019. – №25(4). – С. 51-60 [Kamilova D.P., Yakunina N.A., Ketiladze T.M. Podderzhka lyuteinovoj fazy kak odin iz klyuchevyx faktorov povysheniya e’ffektivnosti vspomogatel’nyx reproduktivnyx texnologij // Probl. Reprod. – 2019. – №25(4). – S. 51-60 (in Russ.)]. https://doi.org/10.17116/repro20192504151

Arabipoor A., Ashrafi M., Hemat M., Zolfaghari Z. The Effects of Maternal and Paternal Body Mass Index on Live Birth Rate after Intracytoplasmic Sperm Injection Cycles // Int. J. Fertil. Steril. – 2019. – Vol. 13(1). – P. 24-31. https://doi.org/10.22074/ijfs.2019.5433

Vaegter K.K., Lakic T.G., Olovsson M., Berglund L., Brodin T., Holte J. Which Factors Are Most Predictive for Live Birth After In Vitro Fertilization and Intracytoplasmic Sperm Injection (IVF/ICSI) Treatments? Analysis of 100 Prospectively Recorded Variables in 8,400 IVF/ICSI Single-Embryo Transfers // Fertil. Steril. – 2017. – Vol. 107. – P. 641-648.e2. https://doi.org/10.1016/j.fertnstert.2016.12.005

Галайко М.В., Рыбина О.В., Литвиненко М.С., Климов Ю.В., Альтшулер Б.Ю., Губкин А.В. Тромбофилия и беременность // Клин. онкогематол. – 2017. – №3. – С. 409-422 [Galajko M.V., Rybina O.V., Litvinenko M.S., Klimov Yu.V., Al’tshuler B.Yu., Gubkin A.V. Trombofiliya i beremennost’ // Klin. onkogematol. – 2017. – №3. – S. 409-422 (in Russ.)]. https://cyberleninka.ru/article/n/trombofiliya-i-beremennost

Бердюгин Е. С. Перспективы и риски экстракорпорального оплодотворения // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и технические науки. – 2019. – № 7. – С. 176-179 [Berdyugin E. S. Perspektivy i riski e’kstrakorporal’nogo oplodotvoreniya // Sovremennaya nauka: aktual’nye problemy teorii i praktiki. Seriya: Estestvennye i texnicheskie nauki. – 2019. – № 7. – S. 176-179 (in Russ.)]. https://medsi.ru/articles/kakie-riskimogut-voznikat-pri-eko-dlya-zdorovya-zhenshchiny/

Li J., Shen J., Zhang X., Peng Y., Zhang Q., Hu L., Reichetzeder C., Zeng S., Li J., Tian M., Gong F., Lin G., Hocher B. Risk factors associated with preterm birth after IVF/ICSI // Sci. Rep. – 2022. – Vol. 12(1). – Art. no. 7944. https://doi.org/10.1038/s41598-022-12149-w

Аншина М.Б., Долгушина Н.В., Колода Ю.А., Корсак В.С., Савина В.М., Смирнова А.А. Терминология вспомогательных репродуктивных технологий: Международный глоссарий // Пробл. Репрод.. – 2019. – №25(1). – С. 6-15 [Anshina M.B., Dolgushina N.V., Koloda Yu.A., Korsak V.S., Savina V.M., Smirnova A.A. Terminologiya vspomogatel’nyx reproduktivnyx texnologij: Mezhdunarodnyj glossarij // Probl. Reprod. – 2019. – №25(1). – S. 6-15 (in Russ.)]. https://doi.org/10.1371/journal.pone.0108287

Сармулдаева Ш., Локшин В. Современные принципы ведения беременности и родов после вспомогательных репродуктивных технологий // Репрод. мед. – 2019. – №1 (38). – С. 37-43 [Sarmuldaeva Sh., Lokshin V. Sovremennye principy vedeniya beremennosti i rodov posle vspomogatel’nyx reproduktivnyx texnologij // Reprod. med. – 2019. – №1 (38). – S. 37-43 (in Russ.)]. https://repromed.kz/index.php/journal/article/view/87

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Published

2023-05-29

How to Cite

[1]
Isenova С., Tileukul Н. , Aripkhanova А., Boran А. and Makulbekova Н. 2023. Features of pregnancy course and management after in vitro fertilization. Reproductive Medicine (Central Asia). 2 (55) (May 2023), 17–24. DOI:https://doi.org/10.37800/RM.2.2023.17-24.

Issue

No. 2 (55) (2023): Reproductive medicine

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Статьи

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