Modern aspects of intrauterine correction of fetus developmental defects: А literature review

Authors

  • N.M. Imangalieva
  • G.K. Nurlanova
  • S.Sh. Isenova
  • M.K. Apselenova ЦПиДКХ
  • L.R. Dadaeva
  • A.Sh. Urkenova

DOI:

https://doi.org/10.37800/RM.1.2024.103-112

Keywords:

Fetal surgery, fetal therapy, pregnancy, tocolysis, mother, congenital anomalies

Abstract

Relevance: Fetal surgery is an operation to open the uterine cavity, surgically correct fetal abnormalities, and return the fetus to the uterus for postoperative recovery and continuation of gestational development. Over the past 45 years, fetal surgery has become a recognized field of innovative surgery. Huge progress has been made in understanding the natural history and pathophysiology of fetal diseases, solving technical problems of fetal surgery, intra- and postoperative care, and monitoring the mother-fetus separation. However, the success and widespread use of fetal surgery is still limited by several unresolved severe issues. Fetal therapy is a logical continuation of fetal diagnosis. The diseases that could potentially be corrected by treating the fetus include fetal urinary disorders.
The study aimed to review the results of invasive fetoscopic interventions and identify modern approaches to the timely and effective correction of intrauterine developmental defects to reduce negative perinatal and maternal consequences.
Materials and Methods: The literature review included domestic (eLibrary, CyberLeninka.ru ) and foreign articles and recommendations (PubMed, Cochrane Library) published in Russian and English over the past 10 years.
Results: Surgery on a baby before birth may seem like science fiction, but prenatal surgery is becoming more common. Fetoscopic surgery allows providing intrauterine care to pregnant women with multiple pregnancies with severe complications. Fetal aortic valvuloplasty can stop the progression of aortic stenosis in mid-pregnancy and reduce the development of hypoplastic left heart syndrome. One of the most exciting developments in human fetal surgery has been the study of wound healing in fetal skin without scarring.
Conclusion: Fetal surgery is a new field that is developing rapidly, and modern methods of antenatal correction can change the natural course and outcome of the disease. However, some differences still need to be resolved. Standardized assessment tools and fetal blood microsampling methods must be developed to ensure further development of clinical protocols. In this regard, the study of the experience of leading centers is extremely relevant for Kazakhstani specialists.

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Published

2024-04-01

How to Cite

[1]
Imangalieva Н. , Nurlanova Г. , Isenova С. , Apselenova М., Dadaeva Л. and Urkenova А. 2024. Modern aspects of intrauterine correction of fetus developmental defects: А literature review . Reproductive Medicine (Central Asia). 1 (Apr. 2024), 103–112. DOI:https://doi.org/10.37800/RM.1.2024.103-112.

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