Impact of coronavirus infection on the female reproductive system: A literature review

Authors

  • S.E. Erkenova КМУ ВШОЗ
  • Sh.M. Moiynbayeva
  • A.M. Auezova
  • A.A. Kauysheva
  • Sh.K. Karibayeva
  • G.G. Bedelbayeva
  • A.S. Nurmatova
  • M.A. Kulmaganbetov

DOI:

https://doi.org/10.37800/RM.2.2023.46-52

Keywords:

COVID-19, SARS-CoV-2, female reproductive system, disruptions in the menstrual cycle, fertility, pregnancy complications

Abstract

Relevance: The COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global crisis in the healthcare system. This virus primarily attacks the respiratory system, causing pneumonia, acute respiratory distress syndrome (ARDS), and, in severe cases, fatality. However, emerging evidence suggests the potential impact of COVID-19 infection on other human systems, including the female reproductive system.

The study aimed to provide a comprehensive overview of the effects of COVID-19 on women’s reproductive health. The review examines existing literature on various aspects, including fertility, pregnancy outcomes, and gynecological health.

Materials and Methods: A comprehensive search was conducted in the PubMed, Scopus, and Embase databases to identify relevant articles on the topic published until January 2023. The search queries included a combination of the following keywords: “COVID-19”, “SARS-CoV-2”, “female reproductive system,” “menstrual cycle,” “pregnancy,” and “fertility.”

Results: The findings of our review indicate that SARS-CoV-2 can have various effects on the female reproductive system. One of the most frequently reported effects is disturbances in the menstrual cycle, including changes in cycle length, duration, and intensity of bleeding. Furthermore, COVID-19 may increase the risk of pregnancy complications, including preterm birth, preeclampsia, and fetal distress.

Conclusion: Existing studies indicate that COVID-19 can significantly impact the female reproductive system, including disruptions in the menstrual cycle and pregnancy complications. However, the precise mechanisms by which the virus affects the reproductive system remain unclear. Further research is needed to gain a deeper understanding of these mechanisms.

References

Taşkaldıran I., Vuraloğlu E., Bozkuş Y., Turhan İyidir Ö., Nar A., & Başçıl Tütüncü N. Menstrual Changes after COVID-19 Infection and COVID-19 Vaccination // Int. J. Сlin. Pract. – 2022. – Art. no. 3199758. https://doi.org/10.1155/2022/3199758

Farland L.V., Khan S.M., Shilen A., Heslin K.M., Ishimwe P., Allen A.M., Herbst-Kralovetz M.M., Mahnert, N.D., Pogreba-Brown K., Ernst K.C., Jacobs E. T. COVID-19 vaccination and changes in the menstrual cycle among vaccinated persons // Fertil. Steril. – 2023. – Vol. 119(3). – P. 392-400. https://doi.org/10.1016/j.fertnstert.2022.12.023

Wang S., Mortazavi J., Hart J.E., Hankins J.A., Katuska L.M., Farland L.V., Gaskins A.J., Wang Y.X., Tamimi R.M., Terry K. L., Rich-Edwards J. W., Missmer S. A., & Chavarro J. E. A prospective study of the association between SARS-CoV-2 infection and COVID-19 vaccination with changes in usual menstrual cycle characteristics // Am. J. Оbstet. Gynecol. – 2022. – Vol. 227(5). – P. 739.e1-739.e11. https://doi.org/10.1016/j.ajog.2022.07.003

Bilgin Z., Çalık K. B. Effect of COVID-19 Vaccines on Menstrual Cycle Changes and Quality of Life // Reprod. Med. Int. – 2022. –Vol. 5(1). – P. 1-8. https://doi.org/10.23937/2643-4555/1710020

Wrapp D., Wang N., Corbett K.S., Goldsmith J. A., Hsieh C. L., Abiona O., Graham B. S., McLellan J.S. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation // Science. – 2020. – Vol. 367(6483). – P. 1260-1263. https://doi.org/10.1126/science.abb2507

Li F., Lu H., Zhang Q., Li X., Wang T., Liu Q., Yang Q., & Qiang L. Impact of COVID-19 on female fertility: a systematic review and meta-analysis protocol // BMJ Open. – 2021. – Vol 11(2). – P.e045524. https://doi.org/10.1136/bmjopen-2020-045524

Mao X.D., Liu K.S., Yao Y.P., Xu Z.R. Potential effects of COVID-19 on reproductive health: a mini review // Am. J. Transl. Res. – 2021. – Vol. 13(12). – P. 13321-13327. https://pubmed.ncbi.nlm.nih.gov/35035678/

Saadedine M., El Sabeh M., Borahay M.A., Daoud G. The influence of COVID-19 infection-associated immune response on the female reproductive system // Biol. Reprod. – 2023. – Vol. 108, Issue 2. – P. 172-182. https://doi.org/10.1093/biolre/ioac187

Jing Y., Run-Qian L., Hao-Ran W., Hao-Ran C., Ya-Bin L., Yang G., Fei C. Potential influence of COVID-19/ACE2 on the female reproductive system // Mol. Hum. Reprod. – 2020. – Vol. 26(6). – P. 367-373. https://doi.org/10.1093/molehr/gaaa030

Wei S.Q., Bilodeau-Bertrand M., Liu S., Auger N. The impact of COVID-19 on pregnancy outcomes: a systematic review and meta-analysis // CMAJ. – 2021. – Vol. 193(16). – P. E540-E548. https://doi.org/10.1503/cmaj.202604

Khalil A., von Dadelszen P., Draycott T., Ugwumadu A., O'Brien P., & Magee, L. Change in the Incidence of Stillbirth and Preterm Delivery During the COVID-19 Pandemic // JAMA. – 2020. – Vol. 324(7). – P. 705-706. https://doi.org/10.1001/jama.2020.12746

Allotey J., Stallings E., Bonet M., Yap M., Chatterjee S., Kew T., Debenham L., Llavall A.C., Dixit A., Zhou D., Balaji R., Lee S.I., Qui X., Yuan M., Coomar D., Sheikh J., Lawson H., Ansari K., Wely M., Leeuwan E., Kostova E., Kunst H., Khalil A., Tiberi S., Brizuela V., Broutet N., Kara E., Kim C.R., Thorson A., Oladapo O.T., Mofenson L., Zamora J., Thangaratinam S. Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis // BMJ. – 2020. – Vol. 370. – P. 3320. https://doi.org/10.1136/bmj.m3320

Martínez-Perez O., Vouga M., Cruz Melguizo S., Forcen Acebal L., Panchaud A., Muñoz-Chápuli M., & Baud D. Association Between Mode of Delivery Among Pregnant Women With COVID-19 and Maternal and Neonatal Outcomes in Spain // JAMA. – 2020. Vol. 324(3). – P. 296-299. https://doi.org/10.1001/jama.2020.10125

Cruz Melguizo S., de la Cruz Conty M. L., Carmona Payán P., Abascal-Saiz A., Pintando Recarte P., González Rodríguez L., Cuenca Marín C., Martínez Varea A., Oreja Cuesta A. B., Rodríguez P. P., Fernández Buhigas I., Rodríguez Gallego M. V., Fernández Alonso A. M., López Pérez R., Broullón Molanes J. R., Encinas Pardilla M. B., Ramírez Gómez M., Gimeno Gimeno M. J., Sánchez Muñoz A., Martínez-Pérez O. On Behalf Of The Spanish Obstetric Emergency Group S O E G Pregnancy Outcomes and SARS-CoV-2 Infection: The Spanish Obstetric Emergency Group Study // Viruses. – 2021. – Vol. 13(5). – P. 853. https://doi.org/10.3390/v13050853

Локшин В.Н., Шарман А.Т., Мирзахметова Д.Д., Терликбаева А.Т., Аимбетова А.Р., Карибаева Ш.К., Уразымбетова К.А. Современные принципы организации специализированной медицинской помощи беременным и родильницам в условиях пандемии коронавируса в Республике Казахстан // Акуш. Гинекол. – 2020. – №12. – С. 34-43 [Lokshin V.N., Sharman A.T., Mirzahmetova D.D., Terlikbaeva A.T., Aimbetova A.R., Karibaeva Sh.K., Urazymbetova K.A. Sovremennye principy organizacii specializirovannoj medicinskoj pomoshhi beremennym i rodil'nicam v uslovijah pandemii koronavirusa v Respublike Kazahstan // Akush. Ginekol. – 2020. – Vol.12. – P. 34-43 (in Russ.)] https://dx.doi.org/10.18565/aig.2020.12.34-43

Жабченко И., Геревич Н., Кравцова Ю., Сюдмак О., Коваленко Т., Бондаренко Е., Лищенко И. Перинатальные последствия COVID-19 (SARS-CoV-2): обзор литературы (часть I) // Репрод. Мед. – 2022. – №1(50). – С. 7-14 [Zhabchenko I., Gerevich N., Kravcova Ju. , Sjudmak O. , Kovalenko T. , Bondarenko E. i Lishhenko I. Perinatal'nye posledstvija COVID-19 (SARS-CoV-2): obzor literatury (chast' I) // Reprod. Med. – 2022. – Vol. 1(50). – S. 7–14. (in Russ.)] https://doi.org/10.37800/RM.1.2022.7-14

Seirafianpour F., Sodagar S., Pour Mohammad A., Panahi P., Mozafarpoor S., Almasi S., Goodarzi A. Cutaneous manifestations and considerations in COVID-19 pandemic: A systematic review // Dermatol. Ther. – 2020. – Vol. 33(6). – P. e13986. https://doi.org/10.1111/dth.13986

Smith H. A. Impact of COVID-19 on neonatal health: Are we causing more harm than good? // Eur. J. Midwifery. – 2020. – P. 1-2. https://doi.org/10.18332/ejm/120245

Mullins E., Evans D., Viner R. M., O'Brien P., Morris E. Coronavirus in pregnancy and delivery: rapid review // Ultrasound Obstet. Gynecol. – 2020. –Vol. 55(5). – P. 586-592. https://doi.org/10.1002/uog.22014

Marquini G.V., Martins S.B., Oliveira L.M., Dias M. M., Takano C.C., Sartori M.G.F. Effects of the COVID-19 Pandemic on Gynecological Health: An Integrative Review // Rev. Bras. Ginecol. Obstet. – 2022. – Vol. 44(2). – P. 194-200. https://doi.org/10.1055/s-0042-1742294

Published

2023-05-29

How to Cite

[1]
Erkenova С. , Moiynbayeva Ш. , Auezova А. , Kauysheva А. , Karibayeva Ш. , Bedelbayeva Г. , Nurmatova А. and Kulmaganbetov М. 2023. Impact of coronavirus infection on the female reproductive system: A literature review. Reproductive Medicine. 2 (55) (May 2023), 46–52. DOI:https://doi.org/10.37800/RM.2.2023.46-52.