Placenta as an important component of the «mother-placenta-fetus» medical-biological system: A literature review
DOI:
https://doi.org/10.37800/RM.3.2023.72-79Keywords:
Placenta, antenatal death, placental insufficiency, fetal hypoxia, pregnancy, immaturity of villi, fetal programmingAbstract
Relevance: To date, there is no single approach between clinicians and morphologists in assessing the role of placental insufficiency in the development of fetal and maternal pathology. This situation is due, firstly, to the complexity of the histological assessment of the degree of compensatory reaction of placental tissue, and secondly, to the assessment of the degree of its maturity and the level of circulatory disorders that affect the features of intrauterine development of the child.
The study aimed to review the placenta examination as an essential component of objective diagnostics to identify prenatal risks for the baby.
Materials and Methods: A comprehensive search was performed in the databases e-Library, Pubmed, Web of Science, Scopus, and Embase to identify relevant articles on the topic published over the past decade. A total of 78 publications were analyzed, of which 47 articles corresponded to the purpose of the study.
Results: By the nature of the structural state of the placenta, it is possible to diagnose vascular and dystrophic changes and verify inflammatory processes of nonspecific and specific genesis. Since the placenta serves as a mirror image of the infectious pathology of the mother, their children are at risk of infection.
Conclusion: Thus, the assessment of the nature of morphological changes in the placenta, both in the relatively physiological course of pregnancy and the presence of pathology of pregnancy and childbirth, with somatic or infectious pathology of the mother, makes it possible to make a prognosis about the condition of the child, both during intrauterine development, and to give a prognostic assessment during the newborn and postnatal period.
References
Баринова И.В., Котов Ю.Б., Кондриков Н.И. Клинико-морфологическая характеристика фетоплацентар- ного комплекса при антенатальной смерти плода // Росс. Вест. Акуш.-Гинекол. – 2013. – №13(3). – C. 14-19 [Barinova I.V., Kotov YU.B., Kondrikov N.I. Kliniko-morfologicheskaya harakteristika fetoplacentarnogo kompleksa pri antenatal'noj smerti ploda // Ross. Vest. Akush.-Ginekol. – 2013. – №13(3). – S. 14-19 (in Russ.)]. https://www.mediasphera.ru/issues/rossijskij-vestnik-akushera-ginekoLoga/2013/3/031726-6122201333
Баринова И.В., Савельев С.В., Котов Ю.Б. Особенности морфологической и пространственной структуры пла- центы при антенатальной гипоксии плода // Росс. Мед.-Биол. Вест. им. акад. И.П. Павлова. – 2015. – №11. – С. 25-29 [Barinova I.V., Savel'ev S.V., Kotov Yu.B. Osobennosti morfologicheskoj i prostranstvennoj struktury placenty pri antenatal'noj gipoksii ploda // Ross. Med.-Biol. Vest. im. akad. I.P. Pavlova. – 2015. – №11. – S. 25-29 (in Russ.)]. https://cyberleninka.ru/article/n/osobennosti-morfologicheskoy-i-prostranstvennoy-struktury-platsenty-pri- antenatalnoy-gipoksii-ploda
Баринова И.В. Патогенез антенатальной смерти: фенотипы плодовых потерь и танатогенез // Росс. Вест. Акуш.-Ги- некол. – 2015. – №15(1). – С. 68-78. [Barinova I.V. Patogenez antenatal'noj smerti: fenotipy plodovyx poter' i tanatogenez // Ross. Vest. Akush.-Ginekol. – 2015. – №15(1). – S. 68-78 (in Russ.)]. https://www.mediasphera.ru/issues/rossijskij-vestnik-akushera-ginekologa/2020/3/downloads/ru/1172661222020031029
Зайдман Л.Н., Камышанский Е.К., Тусупбекова М.М. Латентная хроническая недостаточность плацен- ты с антенатальной гибелью плода сопровождается увеличением CD15+ прогениторов в макроваскуляр- ных сосудах плаценты // Матер. V Съезда Росс. Общ-ва патологоанатомов. – Челябинск. – 1-4 июня 2017 года [ Zajdman L.N., Kamyshanskij E.K., Tusupbekova M.M. Latentnaya xronicheskaya nedostatochnost' placenty s antenatal'noj gibel'yu ploda soprovozhdaetsya uvelicheniem CD15+ progenitorov v makrovaskulyarnyx sosudax placenty // Mater. V S"ezda Ross. Obshh-va patologoanatomov. – Chelyabinsk. – 1-4 iyunya 2017 goda (in Russ.)]. http://patolog.ru/sites/default/files/materialy_sezda_rop.pdf
Seidmann L., Suhan T., Kamyshanskiy Y., Nevmerzhitskaya A., Gerein V., Kirkpatrick C.J. CD15 – A new marker of pathological villous immaturity of the term placenta // Placenta. – 2014. – № 35(11). – P. 925-931. https://pubmed.ncbi.nlm.nih.gov/25149387/
Seidmann L., Suhan T., Unger R., Gerein V., Kirkpatrick C.J. Transient CD15- positive endothelial phenotype in the human placenta correlates with physiological and pathological fetoplacental immaturity // Eur. J. Obstet. Gynecol. Reprod. Biol. – 2014. – Vol. 180. – P. 172-179. https://pubmed.ncbi.nlm.nih.gov/25043745/
Hentschke M.R., Poli-de-Figueiredo C.E., da Costa B.E., Kurlak L.O., Williams P.J., Mistry H.D. Is the atherosclerotic phenotype of preeclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors? Role of a small-for-gestational-age phenotype // J. Lipid. Res. – 2013. – Vol. 54(10). – P. 2658-2564. https://doi.org/10.1194/jlr.M036699
Камышанский Е.К., Костылева О.А., Тусупбекова М.М., Мусабекова С.А., Журавлев С.Н. Нару- шение роста и незрелость плаценты как независимые факторы риска перинатальных осложне- ний // МEDICINE (Almaty). – 2016. – № 12(174). – С. 113-117 [Kamyshanskij E.K., Kostyleva O.A., Tusupbekova M.M., Musabekova S.A., Zhuravlev S.N. Narushenie rosta i nezrelost' placenty kak nezavisimye faktory riska perinatal'nyx oslozhnenij // MEDICINE (Almaty). – 2016. – № 12(174). – S. 113-117 (in Russ.)] http://www.medzdrav.kz/images/magazine/medecine/2016/2016-12/M_12-16_113-117.pdf
Kamyshanskiy Y.K., Bykova T., Bykova S., Altaev N., Dombaev A. Structural placental immaturity – A morphological diagnostic marker for assessment of hypoxic fetal distress // Science4Health 2017: матер. VIII Int. Sci. Conf. – M., 2017. – P. 117-119. https://repository.rudn.ru/ru/recordsources/recordsource/8942/
Heider A. Fetal Vascular Malperfusion // Arch. Pathol. Lab. Med. – 2017. – Vol. 141(11). – P. 1484-1489. https://doi.org/10.5858/arpa.2017-0212-RA
Nikitina I., Boychuk A., Babar Т., Dunaeva М. Prediction of threats to multiple pregnancy interruption depending on the cause of its occurrence // Res. J. Pharm. Biol. Chem. Sci. – 2016. – Vol. 7. – P. 764-771. https://wiadlek.pl/wp-content/uploads/archive/2020/WLek202007123.pdf
Kostyleva O., Stabayeva L., Tussupbekova M., Mukhammad I., Kotov Y., Kossitsyn D., Zhuravlev S.N. Erythroblasts in the Vessels of the Placenta – An Independent Factor of Chronic Hypoxic Damage to the Fetus // Open Access Maced. J. Med. Sci. – 2022. – Vol. 10(A). – P. 1151-1156. https://doi.org/10.3889/oamjms.2022.8745
Lockwood C. Risk factors for preterm birth and new approaches to its early diagnosis // J. Perinatal. Med. – 2015. – S. 43 - 5. https://doi.org/10.1515/jpm-2015-0261 23.
Ожиганова И.Н. Патоморфологические особенности взаимоотношения в системе мать-плацента-плод при ос- ложненном течении беременности: автореферат дис. ... док. мед. наук : 14.00.15. - Новосибирск, 1994. - 52 с.: ил. [Ozhiganova I.N. Patomorfologicheskie osobennosti vzaimootnosheniya v sisteme mat-placenta-plod pri oslozhnennom techenii beremennosti : avtoreferat dis. ... doktora medicinskih nauk : 14.00.15. - Novosibirsk, 1994. - 52 s. : il. (in Russ.)]. http://www.dslib.net/vnutrennie-bolezni/patomorfologicheskie-osobennosti-vzaimootnoshenija-v-sisteme-mat- placenta-plod-pri.html
Bougas A.P., de Souza B.M., Bauer A.C. Role of innate immunity in preeclampsia: A systematic review // Reprod. Sci. – 2017. – Vol. 24. – P. 1362-1370. https://doi.org/10.1177/1933719117691144
Hashemi V. Natural killer T cells in preeclampsia: An updated review /V. Hashemi, S. Dolati, A. Hosseini //Biomed. Pharmacother. – 2017. – Vol. 95. – P. 412-418. https://doi.org/10.1016/j.biopha.2017.08.077
Roescher A.M., Timmer A., Hitzert M.M., de Vries N.K.S., Verhagen E., Erwich J.J.H.M., Bos A. Placental pathology and neurological morbidity in preterm infants during first two weeks after birth // Early Hum. Dev. – 2014. – Vol. 90. – Р. 21-25. https://doi.org/10.1016/j.earlhumdev.2013.11.004
Щеголев А.И. Современная морфологическая классификация повреждений плаценты // Акуш. Гинекол. – 2016. – №4. – С. 16-23 [Shhegolev A.I. Sovremennaya morfologicheskaya klassifikaciya povrezhdenij placenty // Akush. Ginekol. – 2016. – №4. – S. 16-23 (in Russ.)]. https://dx.doi.org/10.18565/aig.2016.4.16-23
Шорманов С.В., Павлов А.В., Гансбургский А.Н., Яльцев А.В. Адаптационные структуры артериального русла плода и плаценты в условиях хронической фетоплацентарной недостаточности // Арх. патол. – 2014. – №3. – C. 41-46 [Shormanov S.V., Pavlov A.V., Gansburgskij A.N., Yal'cev A.V. Adaptacionnye struktury arterial'nogo rusla ploda i placenty v usloviyax xronicheskoj fetoplacentarnoj nedostatochnosti // Arx. patol. – 2014. – №3. – S. 41-46 (in Russ.)]. https://www.mediasphera.ru/issues/arkhiv-patologii/2014/3/downloads/ru/1000419552014031041
Бондаренко В.М., Бондаренко К.Р. Эндотоксинемия в акушерско-гинекологической практике // Terra Medica. – 2014. – №2. – С. 4-8 [Bondarenko V.M., Bondarenko K.R. E'ndotoksinemiya v akushersko-ginekologicheskoj praktike // Terra Medica. – 2014. – №2. – S. 4-8 (in Russ.)]. https://aig-journal.ru/articles/Sostoyanie-sistemy-Mat-placenta-plod-pri-beremennosti-oslojnennoi-inficirovaniem-ploda.html
Фомина М.П., Дивакова Т.С., Ржеусская Л.Д. Эндотелиальная дисфункция и баланс ангиогенных факторов у бере- менных с плацентарными нарушениями // Мед. Нов. – 2014. – №3. – С. 63-67 [Fomina M.P., Divakova T.S., Rzheusskaya L.D. E'ndotelial'naya disfunkciya i balans angiogennyx faktorov u beremennyx s placentarnymi narusheniyami // Med. Nov. – 2014. – №3. – S. 63-67] https://dx.doi.org/10.18565/aig.2016.5.5-10
Grannum P. A., Berkowitz R.L., Hobbins J.C. The ultrasonic changes in the maturing placenta and their relation to fetal pulmonic maturity // Amer. J. Obstet. Gynecol. – 1979. – Vol. 133 (8). – P. 915-922. https://doi.org/10.1016/0002-9378(79)90312-0
Милованов А.П., Расстригина И.М., Фокина Т.В. Морфометрическая оценка плотности распределения и диаметра клеток вневорсинчатого трофобласта в течение условно неосложненной беременности // Арх. Патол. – 2013. – №3. – С. 18-21 [Milovanov A.P., Rasstrigina I.M., Fokina T.V. Morfometricheskaya ocenka plotnosti raspredeleniya i diametra kletok vnevorsinchatogo trofoblasta v techenie uslovno neoslozhnennoj beremennosti // Arx. Patol. – 2013. – №3. – S. 18-21 (in Russ.)]. https://www.mediasphera.ru/issues/arkhiv-patologii/2020/3/1000419552013031018
Аметов А.С. Сахарный диабет 2 типа. Проблемы и решения. – М.: ГЭОТАР-Медиа, 2013 [Ametov A.S. Saxarnyj diabet 2 tipa. Problemy i resheniya. – M.: GE'OTAR-Media, 2013 (in Russ.)]. https://www.volgmed.ru/uploads/dsovet/thesis/6-744-palieva_natalya_viktorovna.pdf
Боташева Т.Л., Линде В.А., Ермолова Н.В., Хлопонина А.В. и соавт. Ангиогенные факторы и цитокины у женщин при физиологической и осложненной беременности в зависимости от пола плода // Таврич. Мед.-Биол. Вест. – 2016. – Т. 19, №2. – С. 22-27 [Botasheva T.L., Linde V.A., Ermolova N.V., Xloponina A.V. i soavt. Angiogennye faktory i citokiny u zhenshhin pri fiziologicheskoj i oslozhnennoj beremennosti v zavisimosti ot pola ploda // Tavrich. Med.-Biol. Vest. – 2016. – T. 19, №2. – S. 22-27 (in Russ.)]. https://cyberleninka.ru/article/n/angiogennye-faktory-i-tsitokiny-u-zhenschin-pri-fiziologicheskoy-i-oslozhnennoy-beremennosti-v-zavisimosti-ot-pola-ploda
Gaillard R., Steegers E.A., Tiemeier H., Hofman A., Jaddoe V.W. Placental vascular dysfunction, fetal and childhood growth, and cardiovascular development: the Generation R study // Circulation. – 2013. – Vol. 128. – P. 2202-2210. https://doi.org/10.1161/CIRCULATIONAHA.113.003881
Lannaman K., Romero R., Chaiworapongsa T., Kim Y.M., Korzeniewski S.J., Maymon E., Gomez-Lopez N., Panaitescu B., Hassan S.S., Yeo L., Yoon B.H., Jai Kim C., Erez O. Fetal death: an extreme manifestation of maternal anti-fetal rejection // J. Perinat. Med. – 2017. – Vol. 45(7). – P. 851-868. https://doi.org/10.1515/jpm-2017-0073
Сармулдаева Ш., Локшин В. Современные принципы ведения беременности и родов после вспомогательных репро- дуктивных технологий // Репрод. мед. – 2019. – №1 (38). – С. 37-43 [Sarmuldaeva Sh., Lokshin V. Sovremennye principy vedeniya beremennosti i rodov posle vspomogatel’nyx reproduktivnyx texnologij // Reprod. med. – 2019. – №1 (38). – S. 37-43 (in Russ.)]. https://repromed.kz/index.php/journal/article/view/87
Газиева И.А. Иммунопатогенетические механизмы формирования плацентарной недостаточности и ранних репродук- тивных потерь: дисс. … д-ра биол. наук: 14.03.09. – Екатеринбург, 2014. – 319 с. [Gazieva I.A. Immunopatogeneticheskie mexanizmy formirovaniya placentarnoj nedostatochnosti i rannix reproduktivnyx poter': diss. … d-ra biol. nauk: 14.03.09. Ekaterinburg; 2014.] https://www.dissercat.com/content/immunopatogeneticheskie-mekhanizmy-formirovaniya-platsentarnoi-nedostatochnosti-i-rannikh-re?ysclid=lmjaek5jp952162043
Chan J.S. Villitis of Unknown Etiology and Massive Chronic Intervillositis // Surg. Pathol. Clin. – 2013. – Vol. 6(1). – P. 115-126. https://doi.org/10.1016/j.path.2012.11.004
Chen A, Roberts DJ. Placental pathologic lesions with a significant recurrence risk – what not to miss! // APMIS. – 2018. – Vol. 126(7). – P. 589-601. https://doi.org/10.1111/apm.12796
Slack J.C., Boyd T.K. Fetal Vascular Malperfusion Due To Long and Hypercoiled Umbilical Cords Resulting in Recurrent Second Trimester Pregnancy Loss: A Case Series and Literature Review // Pediatr. Dev. Pathol. – 2021. – Vol. 24(1). – P. 12-18. https://doi.org/10.1177/1093526620962061
Wang A.C., Xie J.L., Wang Y.N., Sun X.F., Lu L.J., Sun Y.F., Gu Y.Q. [Autopsies and placental examinations of perinatal fetal deaths: a clinicopathological analysis of 105 cases] // Zhonghua Bing Li Xue Za Zhi. – 2022. – Vol. 51(5). – P. 431-436. Chinese. https://doi.org/10.3760/cma.j.cn112151-20210908-00657
Gaillard R., Jaddoe V.W.V. Maternal cardiovascular disorders before and during pregnancy and offspring cardiovascular risk across the life course // Nat. Rev. Cardiol. – 2023. – Vol. 20. – P. 617-630. https://doi.org/10.1038/s41569-023-00869-z
Booker W., Moroz L. Abnormal placentation // Semin. Perinatol. – 2019. – Vol. 43(1). – P. 51-59. https://doi.org/10.1053/j.semperi.2018.11.009
Guimarães G.C., Alves L.A., Betarelli R.P., Guimarães C.S.O., Helmo F.R., Pereira Júnior C.D., Corrêa R.R.M., Zangeronimo M.G. Expression of vascular endothelial growth factor (VEGF) and factor VIII in the gilt placenta and its relation to fetal development // Theriogenology. – 2017. – Vol. 92. – P. 63-68. http://dx.doi.org/10.1016/j.theriogenology.2017.01.002
Sferruzzi-Perri A.N., Sandovici I., Constancia M., Fowden A.L. Placental phenotype and the insulin-like growth factors: resource allocation to fetal growth // J. Physiol. – 2017. – Vol. 595 (15). – P. 5057-5093. https://doi.org/10.1113/JP273330
ЮНИСЕФ. Первый отчет по результатам перинатального аудита в пилотных организациях Республики Казахстан. – Астана, 2018. – 34 с. [YuNISEF. Pervyj otchet po rezultatam perinatalnogo audita v pilotnyh organizaciyah Respubliki Kazahstan. – Astana, 2018. – 34 s. (in Russ.)]. https://www.unicef.org/kazakhstan/media/2701/file/Первый отчет по результатам перинатального аудита в пилотных организациях РК.pdf
Mifsud W., Sebire N.J. Placental pathology in early-onset and late-onset fetal growth restriction // Fetal Diagn. Ther. – 2014. – Vol. 36(2). – P. 117-128. https://doi.org/10.1159/000359969
Kovo M., Schreiber L., Bar J. Placental vascular pathology as a mechanism of disease in pregnancy complications // Thromb. Res. – 2013. – Vol. 131 Suppl. – P. 18-21. https://doi.org/10.1016/S0049-3848(13)70013-6
Brosens I., Puttemans P., Benagiano G. Placental bed research: I. The placental bed: from spiral arteries remodeling to the great obstetrical syndromes // Am. J. Obstet. Gynecol. – 2019. – Vol. 221(5). – P. 437-456. https://doi.org/10.1016/j.ajog.2019.05.044
Fiorimanti M.R., Cristofolini A.L., Rabaglino M.B., Moreira-Espinoza M.J., Grosso M.C., Barbeito C.G., Merkis C.I. Vascular characterization and morphogenesis in porcine placenta at day 40 of gestation // Reprod Domest Anim. - 2023 Jun. - 58(6). – P. 840-850. https://doi.org/10.1111/rda.14357
Sun C., Groom K.M., Oyston C., Chamley L.W., Clark A.R., James J.L. The placenta in fetal growth restriction: What is going wrong? // Placenta. – 2020. – Vol. 96. – P. 10-18. https://doi.org/10.1016/j.placenta.2020.05.003
Keshavarz E., Motevasselian M., Amirnazeri B., Bahramzadeh S., Mohammadkhani H., Mehrjardi Z., Razzaz M., Bakhtiyari M. Gestational age-specific reference values of placental thickness in normal pregnant women // Women Health. – 2019. – Vol. 59(7). – P. 718-729. https://doi.org/10.1080/03630242.2018.1553816
Rudolph A.M. Circulatory changes during gestational development of the sheep and human fetus // Pediatr. Res. – 2018. – Vol. 84(3). – P. 348-351. https://doi.org/10.1038/s41390-018-0094-9
Powe C.E., Levine R.J., Karumanchi S.A. Preeclampsia, a disease of the maternal endothelium: the role of antiangiogenic factors and implications for later cardiovascular disease // Circulation. – 2011. – Vol. 123. – P. 2856-2869. https://doi.org/10.1161/CIRCULATIONAHA.109.853127
Seidmann L., Kamyshanskiy Y., Martin S.Z., Fruth A., Roth W. Immaturity for gestational age of microvasculature and placental barrier in term placentas with high weight // Eur. J. Obstet. Gynecol. Reprod. Biol. – 2017. – Vol. 15. – P. 134-140. https://doi.org/10.1515%2Fjpm-2020-0138
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