Optimization of diagnostic algorithm for jaundice in infants at PHC level: A literature review
DOI:
https://doi.org/10.37800/RM.3.2024.36-41Keywords:
neonatal jaundice, newborns, hyperbilirubinemia, bilirubin, phototherapy, biochemical blood analysis, breastfeeding jaundiceAbstract
Relevance: Jaundice syndrome in young children is determined by its frequent manifestation in newborns and in the first months of life. Timely diagnosis of jaundice in children under one year of age helps prevent serious complications. Jaundice can be physiological (up to 2 weeks in full-term newborns and up to 3 weeks in premature babies) or pathological (from the first two days to more than a month after birth). Early detection and treatment are crucial for the healthy development of the child.
The study aimed to summarize current data on the risk factors and diagnostic significance of jaundice syndrome in early childhood.
Materials and Methods: This review included domestic and foreign publications in the NCBI (PubMed), Scopus, Medline, Google Scholar, CyberLeninka, and eLibrary databases published from 2014 to 2024. Search terms included “jaundice,” “neonatal jaundice,” “hyperbilirubinemia,” “cholestasis,” “hepatitis,” and “newborn,” using the MESH search tool.
Results: Jaundice in early childhood requires early detection and appropriate treatment to prevent severe complications. Risk factors identified include maternal illnesses during pregnancy (ARI, gestational diabetes, anemia), episiotomy during delivery, prolonged oligohydramnios, and insufficient early feeding in the first days. Understanding these factors allows healthcare professionals to provide parents with adequate information and ensure timely treatment for affected newborns.
Conclusion: Recent studies show that jaundice syndrome is common in children under one year of age, especially in newborns. Early detection of jaundice prevents possible long-term complications. Further research is needed to enhance the diagnosis and treatment of jaundice and reduce the incidence of long-term complications in affected children.
References
Горяйнова А.Н., Анцупова М.А., Захарова И.Н. Желтухи здорового новорожденного: причины, течение, прогноз. Мед совет. 2017;19:120-125
Goryainova AN, Antsupova MA, Zakharova IN. Jaundice of a healthy newborn: causes, course, prognosis. Med sovet. 2017;19:120-125. (In Russ.).
https://cyberleninka.ru/article/n/zheltuhi-zdorovogo-novorozhdennogo-prichiny-techenie-prognoz
Володин Н.Н., Дегтярев Д.Н. Тактика ведения доношенных и недоношенных новорожденных с непрямой гипербилирубинемией (клинические рекомендации). Неонатология: Новости. Мнения. Обучение. 2017;2(16):113-132.
Volodin NN, Degtyarev DN. Tactics of management of full-term and premature newborns with indirect hyperbilirubinemia (clinical guidelines). Neonatologiya: Novosti. Mneniya. Obuchenie. 2017;2(16):113-132. (In Russ.).
https://doi.org/10.24411/2308-2402-2017-00035
Мохова О.Г., Канкасова М.Н., Поздеева О.С. Синдром желтухи в практике педиатра. Практ мед. 2018;16(8):43-49.
Mokhova OG, Kankasova MN, Pozdeeva OS. Jaundice syndrome in pediatric practice. Pract Med. 2018;16(8):43-49. (In Russ.).
https://doi.org/10.32000/2072-1757-2018-8-43-49
Захарова И.Н., Горяйнова А.Н., Холодова И.Н., Майкова И.Д., Беленович Е.В. Дифференциальный диагноз желтух у детей раннего возраста. Мед совет. 2016;7:56-65.
Zakharova IN, Goryainova AN, Kholodova IN, Maikova ID, Belenovich EV. Differential diagnosis of jaundice in young children. Med. sovet. 2016;7:56-65.
https://cyberleninka.ru/article/n/differentsialnyy-diagnoz-zheltuh-u-detey-rannego-vozrasta
Волянюк Е.В. Алгоритм диагностики и лечения пролонгированной желтухи у детей первых месяцев жизни. Вестник соврем клин мед. 2016;9(2):42-46.
Volyanyuk EV. Algorithm for diagnosing and treating prolonged jaundice in children in the first months of life. Vestnik sovrem klin med. 2016;9(2):42-46. (In Russ.).
https://doi.org/10.20969/VSKM.2016.9(2).42-46
Гурина Л.Н., Ерохина И.А., Юсевич Н.С., Денисик Н.И. Гипербилирубинемии у новорожденных. Медицина: теория и практика. 2018;3(1):27-28.
Gurina LN, Erokhina IA, Yusevich NS, Denisik NI. Hyperbilirubinemia in newborns. Medicine: theory and practice. 2018;3(1):27-28. (In Russ.).
https://cyberleninka.ru/article/n/giperbilirubinemii-u-novorozhdennyh
Беляева И.А., Бомбардирова Е.П., Курнатовская Е.О. Желтуха грудного молока. Вопр соврем педиатр. 2023;22(6):498-505.
Belyaeva IA, Bombardirova EP, Kurnatovskaya EO. Breast milk jaundice. Vopr sovrem pediatr. 2023;22(6):498-505. (In Russ.).
https://doi.org/10.15690/vsp.v22i6.2656
Ullah S., Rahman K., Hedayati M. Hyperbilirubinemia in neonates: types, causes, clinical examinations, preventive measures, and treatments: A narrative review article. Iranian J Public Health. 2016;5(45):558-568.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935699
Куанышпаева Г.Д., Сартаева Л.Е., Кизатова С.Т. Неонатальные желтухи у новорождённых детей. Росс Педиатр Журн. 2022;25(4);268.
Kuanyshpaeva GD, Sartaeva LE, Kizatova ST. Neonatal'nye zheltuhi u novorozhdyonnyh detej. Ross Pediat Zhurn. 2022;25(4);268. (In Russ.).
https://doi.org/10.46563/1560-9561-2022-25-4-242-292
Boskabadi H, Rakhshanizadeh F, Zakerihamidi M. Evalution of maternal risk factors in neonatal Hyberbilirubinemia. Arch Iran Med. 2020;23(2):128-140.
Aiswarya AT, Sajeeth CI. The incidence, risk factors and management of neonatal jaundice in a government hospital, Palakkad district, Kerala. Int J Health Sci Res. 2016;6(6):123-129. http://www.ijhsr.org/IJHSR_Vol.6_Issue.6_June2016/22.pdf
Mohammad KIS, Al-Shefdat M., Halasa S., Joseph R., Alafi M., ALBashtawy M., Alkhawaldeh A., Abdalrahim A., Malak M., Creedy D., Gamble J. Maternal and neonatal factors associated with neonatal jaundice in Jordan: a case-control study. BJM. 2024;32(3):126-134.
https://doi.org/10.12968/bjom.2024.32.3.126
Khalaf R, Phen K, Karjoo S. Cholestasis beyond the neonatal and infancy periods. Pediatric gastroenterol hepatol nutrit. 2016;1(19):1-11.
https://doi.org/10.5223/pghn.2016.19.1.1
Нургалимов М.К., Абдрахманова А.К., Бакирова Н.А. Эпидемиология желтушного синдрома у детей раннего возраста с врожденными пороками развития желчевыводящих путей. Мол учен. 2020;9(89-92).
Nurgalimov MK, Abdrahmanova AK, Bakirova NA. Epidemiology of icteric syndrome in young children with congenital malformations of the biliary tract. Mol uchen. 2020;9:89-92. (In Russ.).
https://moluch.ru/archive/299/67792/
Memon N, Bari I, Thomas H. Inherited disorders of bilirubin clearance. Pediatr Res. 2016;79(3):378-386.
https://doi.org/10.1038/pr.2015.247
Божбанбаева Н.С., Умешева К.А., Мустафазаде Т.Ш. К проблеме пролонгированных неонатальных желтух. West Kazakhstan Med J. 2015;2(46):32-35.
Bozhbanbaeva NS, Umesheva KA, Mustafazade TSh. On the problem of prolonged neonatal jaundice. West Kazakhstan Med J. 2015;2(46):32-35. (In Russ.).
https://cyberleninka.ru/article/n/k-probleme-prolongirovannyh-neonatalnyh-zheltuh
Ракишева Ж.В., Лепесова М.М. Влияние затяжной желтухи неонатального периода на психомоторное развитие детей первого года жизни. Обзор литературы. Наука и здравоохранение. 2019;3:45-53.
Rakisheva ZhV, Lepesova MM. Vliyanie zatyazhnoj zheltuhi neonatal'nogo perioda na psiho-motornoe razvitie detej pervogo goda zhizni. Obzor literatury. Nauka i zdravoohranenie. 2019;3:45-53. (In Russ.).
Дегтярева А.В., Дегтярев Д.Н. Современные принципы диагностики и лечения негемолитической гипербилирубинемии у доношенных и поздних недоношенных детей в раннем неонатальном периоде. Неонатология: Новости. Мнения. Обучение. 2014;3(5):67-76.
Degtyareva AV, Degtyarev DN. Sovremennye principy diagnostiki i lecheniya negemoliticheskoj giperbilirubinemii u donoshennyh i pozdnih nedonoshennyh detej v rannem neonatal'nom periode. Neonatologiya: Novosti. Mneniya. Obuchenie. 2014;3(5):67-76. (in Russ.).
Тожибоева Д. Желтуха у детей: от младенцев до подростков. Образование, наука и инновационные идеи в мире. 2023;28(1):90-96.
Tozhiboeva D. Jaundice in children: from infants to adolescents. Obrazovanie nauka i innovacionnye idei v mire. 2023;28(1):90-96. (in Russ.).
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 The rights to a manuscript accepted for publication are transferred to the Journal Publisher. When reprinting all or part of the material, the author must refer to the primary publication in this journal.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The articles published in this Journal are licensed under the CC BY-NC-ND 4.0 (Creative Commons Attribution – Non-Commercial – No Derivatives 4.0 International) license, which provides for their non-commercial use only. Under this license, users have the right to copy and distribute the material in copyright but are not permitted to modify or use it for commercial purposes. Full details on the licensing are available at https://creativecommons.org/licenses/by-nc-nd/4.0/.