Взаимосвязи уровня плацентарного фактора роста в крови и моче с исходом родов : клиническое исследование

Sh.B. Kosmuratova; L.K. Ayazbaeva; K.B. Aliyeva; M.B. Dossimbetova

doi:10.37800/RM.1.2025.394

Authors

Sh.B. Kosmuratova НАО «Медицинский университет Астана»
L.K. Ayazbaeva
K.B. Aliyeva
M.B. Dossimbetova

DOI:

https://doi.org/10.37800/RM.1.2025.394

Keywords:

preeclampsia, premature birth, term birth, placental growth factor, blood, urine

Abstract

Relevance: Both the problem of premature birth and the problem of preeclampsia should be treated optimistically since it is in our power to find a solution. Numerous clinical studies are currently underway, testing various strategies aimed at eliminating the causes of preterm birth and preeclampsia. However, everything is not so optimistic - things are moving slowly. Studying the pathogenesis of preeclampsia and preterm birth in a broad sense will help determine the direction of future clinical research.

The study aimed to determine the relationship between the placental growth factor (PLGF) level in blood and urine in the first trimester of pregnancy, considering the outcome of childbirth.

Materials and Methods: This single-center prospective cohort study included 304 women at 10-14 weeks of pregnancy. They were selected by simple random sampling with the method of generating random numbers, and subjects were divided into 2 groups, considering the results of childbirth. All subjects underwent a general clinical examination, previous health status was assessed, gestational age was determined, and PLGF levels in blood and urine were analyzed. Correlation between two quantitative markers was performed using the Spearman correlation test.

Research results and discussion: In the first trimester of pregnancy (10-14 weeks), the concentration of PLGF in blood was 36.6 (12.8-50.03) pg/ml in the main group and 24.46 (14.6-40.6) pg/ml in urine, p < 0.05. Compared to the indicators in the subjects of the comparison group, the PLGF concentration in blood was 35.18 (22.5-51.2) pg/ml, and in the urine, it was 20.42 (13.79-34.14) pg/ml, p < 0.05. PLGF levels in blood and urine had a strong positive correlation with preterm delivery (r = 0.762, p < 0.05) and a significant positive correlation with term delivery (r = 0.605, p < 0.05).

Conclusion: The level of PLGF in the blood and urine has a strong positive correlation with premature and term birth. However, despite the significant correlation, further research is needed to define standardized cutoff values and develop uniform measurement methods that would allow the use of PGF in clinical practice for the early detection of the risk of preterm birth.

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