Rescue intracytoplasmic sperm injection (Re-ICSI) the day after failure of standard in vitro fertilization
DOI:
https://doi.org/10.37800/RM.3.2024.57-64Keywords:
Re-ICSI, TFF, blastocyst, IVF, frozen embryoAbstract
Relevance: According to the literature, total fertilization failure (TFF) in cycles with standard in vitro fertilization (IVF) occurs in 2.3-3.5% of all completed programs. After TFF, late rescue intracytoplasmic sperm injection (Re-ICSI) is performed. There is no consensus in the reviewed literature on the advisability of Re-ICSI.
The study aimed to analyze the received data on Re-ICSI and determine how to manage patients after TFF.
Materials and Methods: This retrospective, cohort, observational, single-center study was conducted in the AVA PETER clinic (St. Petersburg, Russia) from 2009 to the first half of 2023 – cycles with a complete absence of fertilization after standard IVF were analyzed. The study divided patients into two age groups: the first group under 35 and the second group 35 years and older. The age range of patients was 21-45 years (average age – 34.3 years).
Results: The proportion of cycles with TFF in programs with standard IVF was 1.9% in the first group and 3.9% in the second group. The number of embryos available for transfer or cryopreservation in programs with Re-ICSI was 30.9%. In the first group, 72.9% of the programs ended in transfer or cryopreservation. In the second group – 46.9% (p <0.05).
The clinical pregnancy rate (CPR) after Re-ICSI was 27.12% and 8.16% for the first and second groups, respectively (p<0.05). The live birth rate in 108 Re-ICSI procedures was 18.5%, including 18.6% and 6.1% for the first and second groups, respectively (p<0.05). When transferred in fresh CPR cycles – 24%, and in cryocycles, CPR – 37.5% (p<0.05).
Conclusion: Re-ICSI can be recommended in cases of TFF during fertilization by IVF. The resulting zygotes should be cultured to the blastocyst stage, frozen, and transferred in cryocycles. The procedure's effectiveness depends on the patient's age and is significantly reduced for those 35 years and older.
References
О порядке использования вспомогательных репродуктивных технологий, противопоказания и ограничения к их использованию. Приказ Министерства здравоохранения РФ от 31 июля 2020 года, N803н.
On the procedure for using assisted reproductive technologies, contraindications, and restrictions to their use. Order of the Ministry of Health of the Russian Federation of July 31, 2020, N803n. (In Russ).
http://zdrav36ru/files/1607614651_prikaz-803n-mz-vrt-eco.pdf
Intracytoplasmic sperm injection (ICSI) for non-male factor infertility: a committee opinion. Practice Committees of the American Society for Reproductive Medicine for Assisted Reproductive Technology. Fertil Steril. 2020;114(2):239-245.
https://doi.org/10.1016/j.fertnster.2020.05.032
Batha S, Ardestani G, Ocali O, Jarmuz P, Vaughan DA, Barrett CB, Sakkas D. Day after ICSI: eliminating total fertilization failure after conventional ЭКО with high birth rates following cryopreserved blastocyst transfer. Hum Reprod. 2023;38(7):1277-1283.
https://doi.org/10.1093/humrep/dead097
Jiang Y, Yuan JC, Song G, Zhang XH, Miao SB, Wu XH. Comparing the pregnancy outcomes of Re ICSI and ICSI embryos in fresh ET and FET cycles. Biomed Rep. 2023;19(4):66.
https://doi.org/10.3892/br.2023.1648
Paffoni A, Reschini M, Pisaturo V, Guarneri C, Palini S, Vigano P. Should rescue ICSI be re-evaluated considering the deferred transfer of cryopreserved embryos in vitro fertilization cycles? A systematic review and meta-analysis. Reprod Biol Endocrinol. 2021;19(1):121.
https://doi.org/101186/s12958-021-00784-4
Beck-Fruchter R., Lavee M., Weiss A., Geslevich Y., Shalev E. Rescue intracytoplasmic sperm injection: a systematic review. Fertil Steril. 2014;101(3):690-698.
https://doi.org/10.1016/j.fertnstert.2013.12.004
Ильмуратова СХ, Манжуова ЛН, Локшин ВН. Особенности состояния здоровья детей, родившихся в результате применения вспомогательных репродуктивных технологий. Репрод мед. 2022;2(50):15-20.
Il'muratova SH, Manzhuova LN, Lokshin VN. Osobennosti sostojanija zdorov'ja detej, rodivshihsja v rezul'tate primenenija vspomogatel'nyh reproduktivnyh tehnologij. Reprod med. 2022;2(50):15-20. (In Russ.)
https://doi.org/10.37800/RM.1.2022.15-22
Нигматов К.Т., Карибаева Ш.К., Абшекенова А.Т., Рыбина А.Н., Бегимбаева А.А., Джансугурова Л.Б., Локшин В.Н. Сравнительный анализ программ с использованием нативных и витрифицированных ооцитов в процедурах экстракорпорального оплодотворения. Репрод Мед. 2020;1(42):14-17.
Nigmatov KT, Karibaeva ShK, Abshekenova AT, Rybina AN, Begimbaeva AA, Dzhansugurova LB, Lokshin VN. Comparative analysis of programs using native and cryopreserved oocytes in -virto fertilization procedures. Reprod Med. 2020;1(42):14-17. (In Russ.).
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 The rights to a manuscript accepted for publication are transferred to the Journal Publisher. When reprinting all or part of the material, the author must refer to the primary publication in this journal.
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The articles published in this Journal are licensed under the CC BY-NC-ND 4.0 (Creative Commons Attribution – Non-Commercial – No Derivatives 4.0 International) license, which provides for their non-commercial use only. Under this license, users have the right to copy and distribute the material in copyright but are not permitted to modify or use it for commercial purposes. Full details on the licensing are available at https://creativecommons.org/licenses/by-nc-nd/4.0/.
