Evaluation of coagulogram parameters for predicting early pregnancy loss
DOI:
https://doi.org/10.37800/RM.3.2024.82-91Keywords:
blood clotting factors, blood clotting disorders, early pregnancy loss, thrombosis factorsAbstract
Relevance: To date, there are conflicting data regarding the diagnostic value of coagulogram results and the number of platelets for repeated screening for miscarriage among the general population of women of reproductive age. Thus, in this study, we sought to assess the prognostic potential of existing coagulogram and platelet screening tests in predicting hemorheological disorders associated with early pregnancy loss.
The study aimed to study the prognostic value of coagulation parameters about the outcomes of reproductive losses.
Materials and methods: This retrospective case-control study included 215 women of reproductive age who were divided into two groups: the main group (n=127) consisted of those who had reproductive losses and had two or more adverse pregnancy outcomes during up to 13 weeks of pregnancy; the control group (n=88) consisted of healthy pregnant women who had no history of adverse pregnancy outcomes during up to 13 weeks of pregnancy. A comparative analysis of the listed laboratory parameters of coagulogram and platelet count in these groups was conducted using the nonparametric Mann-Whitney U–test. Logistic regression analysis was used to predict adverse pregnancy outcomes.
Results: In predicting adverse pregnancy outcomes in clinical practice, the use of statistically significant parameters (fibrinogen, platelets) led to a 63.26% probability of reproductive failure. Using coagulogram parameters in the logistic regression model (χ2=10.637; p=0.10030) to predict the risk of reproductive failure showed the probability of reproductive loss of 62.33%. These indicators of reproductive loss did not differ significantly. Coagulogram indicators have a low prognostic potential for predicting adverse pregnancy outcomes based on violations of the body’s blood clotting constants.
Conclusion: The use of laboratory coagulogram parameters (activated partial thromboplastin time, prothrombin time, international normalized ratio, and prothrombin index) and platelet count had no prognostic value about the outcomes of reproductive losses.
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