Долгосрочные последствия ИКСИ: оценка здоровья детей, зачатых с помощью интрацитоплазматической инъекции сперматозоида (обзор литературы)

S. Ilmuratova; V. Lokshin; L. Manzhuova; Zh. Nurgaliyeva; D.I. Marapov; G. Mukhambetova; A.Y. Kalidinova

doi:10.37800/RM.3.2025.568

Authors

S. Ilmuratova Persona
V. Lokshin
L. Manzhuova
Zh. Nurgaliyeva
D.I. Marapov
G. Mukhambetova
A.Y. Kalidinova

DOI:

https://doi.org/10.37800/RM.3.2025.568

Keywords:

ART, ICSI, male infertility, offspring health, reproductive health, endocrine disorders

Abstract

Relevance: The widespread use of intracytoplasmic sperm injection (ICSI) as part of assisted reproductive technologies (ART) requires a comprehensive assessment of its impact on children's health. Despite existing research, data on the health of ICSI-conceived offspring remain controversial.

The study aimed to analyze current data on the health of children born after ICSI to identify potential features of their general somatic, physical, and pubertal development, and assess the risks of endocrine system disorders and congenital malformations.

Methods: We conducted a literature search in databases (Medline, Scopus, Web of Science, etc.) using key terms. Studies in English and Russian meeting the inclusion criteria were reviewed.

Results: Over 30 years of ICSI application, data have been accumulated showing normal physical and cognitive development in children. However, potential risks were identified: metabolic disorders (obesity, insulin resistance), changes in reproductive parameters (FSH and inhibin B levels), and increased frequency of urogenital anomalies. Additionally, differences were observed in total sperm count, motility, and morphology. The conducted review allows us to conclude that existing studies do not fully explore the relationship between the etiology of paternal infertility and the health status of offspring after ICSI. This knowledge gap complicates the assessment of the risks of inheriting reproductive pathologies.

Conclusion: Further research is needed to understand the long-term consequences of ICSI, particularly regarding the reproductive and endocrine health of offspring.

References

Adamson GD, Creighton P, de Mouzon J, Zegers-Hochschild F, Dyer S, Chambers GM. How many infants have been born with the help of assisted reproductive technology? Fertil Steril 2025;124:40–50. https://doi.org/10.1016/j.fertnstert.2025.02.009.

Nurgaliyeva Z, Ilmuratova S, Lokshin V, Manzhuova L, Seisebayeva R. Identifying risk factors for neonatal hypoglycemia in infants conceived through assisted reproductive technology: A retrospective cohort study. Acta Biomed 2025;96:16891–16891. https://doi.org/10.23750/ABM.V96I2.16891.

Ilmuratova S, Manzhuova L, Lokshin V. Health status of children born after assisted reproductive technologies. Reproductive Medicine 2022:15–22. https://doi.org/10.37800/RM.1.2022.15-22.

Issenova SS, Bazarbayeva, Issina GM, Nurlanova GK, Kabyl BK, Sultanmuratova DD, et al. Прогностическая значимость факторов риска преждевременных родов: ретроспективное когортное исследование. Репродуктивная Медицина (Центральная Азия) 2025;2025:85–94. https://doi.org/10.37800/RM.1.2025.461.

Catford SR, McLachlan RI, O’Bryan MK, Halliday JL. Long-term follow-up of intra-cytoplasmic sperm injection-conceived offspring compared with in vitro fertilization-conceived offspring: a systematic review of health outcomes beyond the neonatal period. Andrology 2017;5:610–21. https://doi.org/10.1111/ANDR.12369.

Henningsen A-KA, Opdahl S, Wennerholm U-B, Tiitinen A, Rasmussen S, Romundstad LB, et al. Risk of congenital malformations in live-born singletons conceived with ICSI: a Nordic study from the CoNARTaS group. Fertil Steril 2023. https://doi.org/10.1016/J.FERTNSTERT.2023.07.003.

Catford SR, Halliday J, Lewis S, O’Bryan MK, Handelsman DJ, Hart RJ, et al. The metabolic health of young men conceived using intracytoplasmic sperm injection. Hum Reprod 2022;37:2908–20. https://doi.org/10.1093/HUMREP/DEAC212.

Zhang B, Ban M, Chen X, Hu J, Cui L, Chen ZJ. Altered metabolic profiles in male offspring conceived from intracytoplasmic sperm injection. BMC Med 2024;22:462. https://doi.org/10.1186/S12916-024-03654-Y/FIGURES/3.

Wod M, Thorarinsson CT, Jølving LR, Nielsen J, Friedman S, Fedder J, et al. Selected chronic diseases in children and adolescents conceived with intracytoplasmic sperm injection. European Journal of Obstetrics & Gynecology and Reproductive Biology 2025;304:127–33. https://doi.org/10.1016/J.EJOGRB.2024.11.023.

Catford SR, McLachlan RI, O’Bryan MK, Halliday JL. Long-term follow-up of ICSI-conceived offspring compared with spontaneously conceived offspring: a systematic review of health outcomes beyond the neonatal period. Andrology 2018;6:635–53. https://doi.org/10.1111/ANDR.12526.

Hansen M, Greenop KR, Bourke J, Baynam G, Hart RJ, Leonard H. Intellectual Disability in Children Conceived Using Assisted Reproductive Technology. Pediatrics 2018;142. https://doi.org/10.1542/PEDS.2018-1269.

Belva F, Bonduelle M, Roelants M, Michielsen D, Van Steirteghem A, Verheyen G, et al. Semen quality of young adult ICSI offspring: the first results. Human Reproduction 2016;31:2811–20. https://doi.org/10.1093/HUMREP/DEW245.

Aliani F, Haghshenas Z, Dizaj AV, Arabipoor A, Vesali S, Ashrafi M. Birth prevalence of genital anomalies among males conceived by intracytoplasmic sperm injection cycles: A cross-sectional study. Int J Reprod Biomed 2023;21:53. https://doi.org/10.18502/IJRM.V21I1.12666.

Belva F, Roelants M, De Schepper J, Van Steirteghem A, Tournaye H, Bonduelle M. Reproductive hormones of ICSI-conceived young adult men: the first results. Human Reproduction 2017;32:439–46. https://doi.org/10.1093/HUMREP/DEW324.

Belva F, Bonduelle M, Tournaye H. Endocrine and reproductive profile of boys and young adults conceived after ICSI. Curr Opin Obstet Gynecol 2019;31:163–9. https://doi.org/10.1097/GCO.0000000000000538.

Cooper TG, Noonan E, von Eckardstein S, Auger J, Baker HWG, Behre HM, et al. World Health Organization reference values for human semen characteristics. Hum Reprod Update 2010;16:231–45. https://doi.org/10.1093/HUMUPD/DMP048.

Sciorio R, Esteves SC. Contemporary Use of ICSI and Epigenetic Risks to Future Generations. Journal of Clinical Medicine 2022, Vol 11, Page 2135 2022;11:2135. https://doi.org/10.3390/JCM11082135.